清心开窍方对AD模型小鼠学习记忆能力及脑组织NO AchE含量的影响

Effect of the QINGXin Kaiqiaofang Treat AD Mice on Learning and Memory Ability and Contents of NO AchE in Mice's Brain

目的：探讨清心开窍方对AD模型小鼠学习记忆能力的影响及其机制。方法：动物实验采用对照观察法。对照组用清心开窍方治疗，治疗组用脑复康治疗，9周后评定疗效。结果：中药各组能明显改善AD小鼠学习记忆能力，与对照组比较有显著性差异（P〈0．05—0．01）；中药各组均可降低AD小鼠脑组织中NO、NOS含量及AchE活性，与模型组比较有统计学意义（P〈0．05～0．01）。结论：清心开窍方能改善AD小鼠学习记忆的能力而对AD病具奄治疗作甩。

Objective ： To study the effects of the Qingxin Kaiqiaofang treat AD mices on learning and memory - ability and its mechanism. Methods： Animal test used comparison method;treatment groupsused Qingxin Kaiqiaofang , comparison group used Piracetm, judge curative effect after 9 weeks. Results： Learning and memory ability of Qiagxin Kaiqiaofang groups is improved, companed with comparisongroup, the difference is notable （ P 〈 0.05 - 0.01 ）. The conterts of NO, NOS and AchE in mice were lower, compared with comparison group, the difference is notable（ P 〈 0.05 - 0.01 ）. Conclusion ： Qingxin Kaiqiaofang improved learning and memory ability of AD mices, and treat Alzheimer disease.