丹红注射液配合无创机械通气治疗慢性阻塞性肺病伴2型呼吸衰竭的临床观察

Clinical Observation of Danhong Injection Cooperate with Mechanical Ventiation Treating Chronic Obstructuve Pulmonary Disease Complicating with TypeⅡ Respiratory Failure

目的:观察丹红注射液配合创机械通气治疗慢性阻塞性肺病伴2型呼吸衰竭临床疗效。方法:将78例患者随机分为观察组40例9(A组)和对照组38例(B组),两组患者均予以常规西药及BiPAP呼吸机进行无创性间歇正压通气治疗,观察组同时予以丹红注射液静脉滴注。比较两组患者治疗后临床疗效,血液流变学指标,血气变化参数指标。结果:总有效率(临床控制+显效+有效)差异有显著性(P<0.05)。A组治疗后血浆黏度值、红细胞比容、血红蛋白与治疗比较有非常显著差异(P<0.01),红细胞计数、血小板计数与治疗前比较有显著差异(P<0.05)。B组治疗后血浆黏度值、红细胞比容、血红蛋白与治疗比较有显著差异(P<0.05),红细胞计数、血小板计数与治疗前比较虽然有所下降,但差异不显著(P>0.05)。治疗6天后,A组PH值、PaO2、PaCO2有非常显著差异性(P<0.01),B组PaCO2有非常显著差异性(P<0.01),PH值、PaO2有显著差异(P<0.05)。结论:丹红注射液配合创机械通气治疗慢性阻塞性肺病伴2型呼吸衰竭能提高临床总有效率,显著改善患者通气功能、血液流变性。

Objective： this study objective is to investigate the clinical effieacy of Danhong injection co -operate with mechanical ventilation treating chronic obstructive pulmonary disease （COPD） complicating with type Ⅱ respiratory failure. Methods ：78 cases of patients with COPD complicating with type Ⅱ respiratory failure were divided randomly into 2 groups （treatment group and control group）. The patients in all groups were treated with routine medical therapy and noninvasive positive pressure ventilation using BiPAP ventilator, and the patients in treatment group were intravenously injected with Danhong injection simultaneously. Clinical index, hemorheology index and arterial blood gas parameters were observed before and after treatment. Result ： The total effective rate （ clinical control ＋ curative ＋ effective ） before and after treatment showed significantly difference （ P 〈 0.05 ）. The whole blood viscosity, hematocrit value, Hb value improved significantly after treatment in treatment group（ P 〈0.01 ）. RBC and PLT count showed obviously difference after treatment compared to before treatment （ P 〈 0.05 ）. The whole blood viscosity, hematocrit value, Hb value showed obviously difference after treatment in treatment group （ P 〈 0.05 ）. RBC and PLT count decrease after treatment, however no significantly（ P 〉 0.05 ）. After treated for 6 days, PH, PaO2 ,PaCO2 of patients in treatment group showed significantly difference （ P 〈 0.01 ） . PaCO2 increased significantly, whereas PH and PaO2 increased obviously in control group （ P 〈 0. 05 ）. Conclusion： Danhong injection cooperate with mechanical ventilation treating chronic obstructive pulmonary disease （COPD） complicating with type Ⅱ respiratory failure could promote the total clinical effective rate, significantly improve hemorheology and ventilation function of patients .