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新型非核苷类HIV逆转录酶抑制剂DCK的研究进展 被引量：2

Progress in the new nonnucleoside anti-HIV reverse transcriptase inhibitor-DCK
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摘要 DCK是以天然产物为先导化合物经结构修饰得到的一个高活性抗HIV化合物,其作用机制独特,不同于现有的非核苷类逆转录酶抑制剂,高效低毒,有可能发展成为一类新的抗HIV药物。近年来以它为先导化合物进行了多方面的结构修饰,以期得到药用性质更好的化合物。本文就DCK的发现、结构修饰、构效关系及最新进展予以介绍。 3＇ ,4＇-Di-O-（S）-comphanoyl-（ ＋ ）-c/s-khellactone （DCK） is a synthetic khellactone ester that exhibits potent anti-HIV activity with a mechanism distinct from clinically used anti-HIV agents. Several series of DCK analoges have been synthesized and evaluated for inhibitory effects against HIV. This review article describes recent progress in the discovery, structural modification, and structure-activity relationship studies of potent anti-HIV DCK derivatives.
作者 郭焕芳 谢蓝
机构地区 北京毒理药理研究所
出处 《药学学报》 CAS CSCD 北大核心 2008年第10期997-1002,共6页 Acta Pharmaceutica Sinica
基金 北京市科委"针对重大疾病的创新药物研究"专项基金资助项目(D0204003041631)
关键词 DCK 非核苷类逆转录酶抑制剂 艾滋病 人类免疫缺陷病毒 DCK nonnucleoside anti-HIV reverse transcriptase inhibitor AIDS HIV
分类号 R916 [医药卫生—药学]
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参考文献22

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二级引证文献3

药学学报
2008年 第10期

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