过去25年中国有生育力男性精液参数变化的回顾性研究

Changes of Semen Parameters in Chinese Fertile Men in the Past 25 Years

目的:分析1980～2005年间我国有生育力男性精液参数的变化状况。方法:通过回顾性研究的方式收集相关数据进行分析。结果:收集了25年来自14个省市的共计5834名有生育力男性的精液参数,控制禁欲时间、总睾丸体积等,并去除年龄参数后统计分析显示,随着样本采集年代的不同1996～2000年组精子密度比1980～1995年组呈现显著下降(P<0.0001),而1996～2000年组以后的10年间没有明显变化(P>0.05);精子活动率变化不受样本采集年代的影响(P>0.05),而是随着研究对象年龄的增加而呈现降低;精子总数与精子密度的变化相似,1996～2000年组以前呈现下降(P<0.05),而此后的10年间没有明显变化(P>0.05)。结论:过去25年间中国有生育力男性精液参数中精子密度和精子总数呈现下降,但自1996年后的10年以来没有明显降低;精子活动率不存在与时间相关的变化。

Objective ： To analyze the changes of seminal parameters in Chinese fertile men during the past 25 years. Methods ： We collected semen samples from 5,834 fertile men in 14 different provinces （ including Beijing） between 1980 and 2005 and retrospectively studied their seminal parameters, abstinence durations and total testis volumes by meta-analysis. Results： Compared with the first 15 years, a significant decrease was observed in both sperm density and total number of sperm per ejaculate in the semen samples collected between 1996-2000 （P 〈 0.000 1 and P 〈 0.05 ）, but not obvious in those between 1996-2000 and after 2005 （P 〉 0.05 ）. As for sperm motility, no time-related changes were noted （ P 〉 0.05 ） except a reduction with the increase of age. Conclusion ： There was a decline in sperm density and total number of sperm per ejaculate in Chinese fertile men over the past 25 years, although not significant in the latter 10 years since 1996, but with no time-related changes in sperm motility.