脑外伤患者P300与神经行为认知状态测试相关性研究

P300 correlates with neurobehavioral cognitive status in patients with traumatic brain injury

目的探讨脑外伤患者P300电位与认知的相关性，分析其临床意义。方法采用随机对照方法，分别用事件相关电位和神经行为认知状态测试表（NCSE）对30例不同程度脑外伤患者（病例组）和20例无脑外伤病史志愿者（对照组）进行检测，经正规康复治疗2个月后再次测定病例组P300与NCSE评分，观察其变化，分析其相关性。结果病例组各记录点N200、P300潜伏期明显较对照组延长，而NCSE评分低于对照组；病例组P300潜伏期与NCSE总评分呈负相关（r=-0．679，P〈0．01）；P300与NCSE各项评分进行逐步回归多元分析，定向、判断与P300潜伏期相关性大；正规治疗2个月后NCSE评分提高，P300潜伏期较前明显缩短（P〈0．01）。结论P300可作为认知评定的有效方法，且空间时间定向能力、判断能力对P300潜伏期影响较大。

Objective To explore the correlation between P300 and cognition, and to analyze its clinical meaning. Methods Thirty patients with traumatic brain injury diagnosed with a definite trauma history were recruited as the experimental group, and 20 normal subjects served as controls. All were examined with event-related potentials and the neurobehavioral cognitive status examination （NCSE）. After two months of regular rehabilitation treatment, they were examined again with the same methods to observe any changes. Results N200 and P300 latencies in the experimental group were significantly longer compared with the control group, while the NCSE scores in the experimental group were significantly lower than in the control group. After two months of regular treatment, the NCSE scores rose and N200 and P300 latencies were significantly shorter than before. The P300 lateneies and the NCSE scores were observed to be significantly correlated （r = -0. 679,P≤0.01 ）. Stepwise regression and multivariate analysis revealed that orientation ability and judgment were the components of the NCSE most closely correlated with the P300 latencies. Conclusion P300 latency can serve for the evaluation of cognition due to its significant correlation with orientation ability and time and space judgment.