期刊文献+

脊髓损伤修复研究的现状与展望 被引量:5

下载PDF
导出
摘要 2006年统计数据显示,全世界脊髓损伤(spinal cord injury,SCI)的患病率为(233~755)/百万,年发病率为(10.4~83)/百万。各国学者多年来尝试多种方法试图攻克这一难题.尽管许多研究在相关基础领域取得了一定的进展,但这些进展并没有获得显著的功能恢复。SCI的治疗仍然是世界性医学难题。这主要是由于脊髓损伤的修复不同于其他组织的修复.不仅要求对神经组织位置和形态上的修复,而且要求功能上的替代和修复。同时因为对神经元发育过程了解有限,导致目前很多研究结果同预期大相径庭,甚至是南辕北辙。因此,有学者提出应该调整脊髓损伤修复研究的思路,也提出了一些新的对策。笔者对此作一综述.
作者 沈慧勇 刘鹄
出处 《中国脊柱脊髓杂志》 CAS CSCD 2008年第10期785-788,共4页 Chinese Journal of Spine and Spinal Cord
  • 相关文献

参考文献38

  • 1Wyndaele M,Wyndaele JJ. Incidence,prevalence and epidemiology of spinal cord injury:what learns a worldwide literature survey[J]?Spinal Cord,2006,44(9) :523-529.
  • 2Bregman BS,Kunkel-Bagden E,Schnell L,et al.Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors[J].Nature, 1995,378 ( 6556 ) :498-501.
  • 3Lazar DA,Ellegala DB,Avellino AM,et al.Modulation of macrophage and microglial responses to axonal injury in the peripheral and central nervous systems[J].Neurosurgery,1999,45 (3) :593-600.
  • 4Raineteau O,Fouad K,Noth P,et al.Functional switch between motor tracts in the presence of the mAb IN-1 in the adult rat[J].Proc Natl Acad Sci USA, 2001,98 ( 12 ) : 6929-6934.
  • 5Domeniconi M,Cao Z,Spencer T,et al. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite ontgrowth[J].Nenron, 2002,35 (2) :283-290.
  • 6GrandPre T,Li S,Strittmatter SM. Nogo-66 receptor antagonist peptide promotes axonal regeneration [J].Nature,2002,417 (6888) : 547-551.
  • 7Zheng B,Atwal J, Ho C, et al. Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo [J].Proc Natl Acad Sci USA ,2005,102(4) : 1205-1210.
  • 8Bradbury EJ,Moon LD,Popat RJ, et al. Chondroitinase ABC promotes functional recovery after spinal cord injury[J].Nature, 2002,416(6881 ) :636-640.
  • 9Yick LW, Cheung PT, So KF, et al. Axonal regeneration of Clarke's neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC [J].Exp Neurol,2003,182 (1) : 160-168.
  • 10Grill R,Murai K,Blesch A, et al. Cellular delivery of neurotrophin-3 promotes eorticospinal axonal growth and partial functional recovery after spinal cord injury [J].J Neurosci, 1997,17(14) :5560-5572.

二级参考文献19

  • 1莱维坦I.B. 卡茨马克LK著.舒斯云 包新民译.神经元:细胞和分子生物学[M].北京:科学出版社,2001.10-12.
  • 2Wang ZG, Lv XY, Gu XS, et al. Microelectronic detecting processing and rebuilding of central neural signals [A]. Joint Symposium on Opto-Microelectronic Devices and Circuits [ C ].Wu han:2004.22-26.
  • 3Wise KD, Anderson DJ, Hetke JF, et al. Wireless implantable microsystems:Coming breakthroughs in health care [ A ] .Symposium on VLSI Circuits Digest of Technical Papers [ C ]. HONOLULU:2002.106-109.
  • 4Moxon KA. Brain-control interfaces for sensory and motor prosthetic devices [A]. IEEE International Conference on Acoustics, Speech, and Signal Processing Proceedings [ C ]. Salt lake City:2001.3445-3448.
  • 5Normann RA, Maynard EM, Rousche PJ, et al. Interface for a cortical vision prosthesis [J ]. Vision Res, 1999,39:2577-2587.
  • 6Dario P, Garzella P, Toro M, et al. Neural interfaces for regenerated nerve stimulation and recording [J].IEEE Trans Rehab Eng, 1998,6: 353-363.
  • 7Kovacs GTA, Storment CW, Rosen JM. Regeneration microelectrode array for peripheral nerve recording and stimulation [J]. IEEE Trans BME, 1992,39: 893-902.
  • 8Rise,R Mark T. Instrumentation for Neuromodulation [J]. Arch Med Res, 2000,31: 237-247.
  • 9Naples GG, Mortimer JT, Scheiner, A, et al. A spiral nerve cuff electrode for peripheral nerve stimulation [J]. IEEE Trans BME,1988,35:905-906.
  • 10Meyer JU, Schuttler M, Thielecke H, et al. Biomedical microdevices for neural interfaces [A]. Frist Annual International France Congress Microtechnologies in Medicine and Biology [ C ]. Palais:2000. 447-453.

共引文献3

同被引文献108

引证文献5

二级引证文献126

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部