FAK-ERK的研究进展及其法医学应用价值

Advances in the study on FAK-ERK and its applicable value in forensic medicine

细胞内黏着斑激酶(focal adhesion kinase,FAK)和细胞外信号调节蛋白激酶(extracellular signal-regulatedprotein kinase,ERK)均是重要的信号转导分子,二者在信号从表面受体转导至细胞核过程中起到关键作用。当受到细胞外刺激时,FAK被激活而发生磷酸化,磷酸化的FAK激活下游的ERK,通过ERK改变细胞行为。这样,FAK-ERK信号传导因子就参与了细胞增殖、分化、应激、凋亡和恶变等多种生物学反应。本文对FAK-ERK的生物学特性以及其在组织损伤中作用的研究进展作一综述,以期为组织损伤时间推断的法医学研究提供更为有效的方法。

Focal adhesion kinase （FAK）and extracellular signal-regulated protein kinase （ERK）, which are thought to play major roles in transducing surface receptor-derived signals into nucleus, are pivotal signal transduction molecules in mammalian cells. FAK is activated through phosphorylation by extraceUular stimuli, p-FAK activates the downstream of ERK which changes cell action. FAK-ERK signal conduction factors are involved in a variety of biological responses, such as cell proliferation, differentiation, stress, apoptosis and malignant change. The biologic characters of FAK-ERK and advances in the study on its roles in tissue damage are reviewed in this article, which may provide a more effective way for estimation of wound age in forensic medicine.