bcl-2反义寡核苷酸体外净化急性髓细胞白血病骨髓的研究
摘要
有效地体外净化自体造血干细胞移植（AHSCT）的移植物是减少移植后复发及提高疗效的重要手段，当前研究的净化方法还存在一些局限性，或不能彻底清除恶性克隆细胞，或对正常细胞有毒性作用，影响造血功能恢复。由于Bcl-2蛋白在急性髓细胞白血病（AML）的高表达，而且与化疗后白血病细胞残留及耐药直接相关，我们选用bcl-2反义寡核苷酸（bcl-2 AS-ODN）从基因水平阻断bcl-2的转录和表达，研究其对缓解骨髓细胞中残留的白血病细胞的凋亡诱导作用，及其对正常骨髓细胞的生长和造血功能的影响。
出处
《中华内科杂志》
CAS
CSCD
北大核心
2008年第10期838-839,共2页
Chinese Journal of Internal Medicine
基金
福建省教育厅科研基金（K2001075）
福建省卫生厅青年科研基金（Y2K-1-05）
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