可疑肾动脉狭窄患者行肾动脉支架植入及开搏通试验前后脑钠肽的变化

Changes in brain natriuretic peptide levels before and after Capoten test as well as renal artery intervention in patients with suspected renal artery stenosis

选择2007-06/2008-03本院心内科收治的可疑肾动脉狭窄引起的高血压患者40例,男28例,女12例,平均年龄(60.0±15.6)岁。行开搏通试验及肾动脉造影,测定患者行开搏通试验及肾动脉支架植入前后脑钠肽的变化。40例可疑肾动脉狭窄行开搏通试验者,30例试验阳性,10例试验阴性;30例试验阳性者其试验前后脑钠肽含量差异具有显著性意义(P<0.05);10例阴性患者其试验前后脑钠肽含量差异无显著性意义(P>0.05)。对30例阳性患者行肾动脉造影,23例行支架植入,支架植入前后脑钠肽含量差异具有显著性意义(P<0.05);对10例阴性患者行肾动脉造影,3例行支架植入,支架植入前后脑钠肽含量差异无显著性意义(P>0.05)。结果说明对于高度可疑肾动脉狭窄患者,脑钠肽水平可用于诊断及评价肾动脉狭窄患者支架植入的可能疗效。

Forty patients with hypertension suspected to stenosis of renal artery were selected from Department of Cardiology, General Hospital of Chinese PLA between June 2007 and March 2008, including 28 males and 12 females with an average age of （60.0±15.6）. Capoten test and renal artery angioplasty were performed in all patients to detect brain natriuretic peptide changes before and after the Capoten test and renal artery stent implantation. Among 40 patients underwent Capoten test, 30 showed positive result and 10 negative. The levels of brain natriuretic peptide before and after Capoten test in patients with positive result were statistically different （P 〈 0.05）. But there was no statistical difference in patients with negative Capoten test （P 〉 0.05）. Among thirty patients with positive Capoten test undergoing renal artery angioplasty, twenty-three patients underwent stent implantation, and their brain natriuretic peptide showed statistical differences between before and after stent implantation （P 〈 0.05）. Among ten patients with negative Capoten test undergoing renal artery angioplasty, three patients underwent stent implantation, and there was no significant difference in brain natriuretic peptide between before and after stent implantation （P 〉 0.05）. The results of the study show that levels of brain natriuretic peptide can be used to evaluate possible effect of stent implantation for patients with hypertension suspected to stenosis of renal artery.