生长抑素受体1～3亚型蛋白在胃癌中的表达及临床意义

Expressions of somatostatin receptor subtypes 1～3 in gastric carcinoma

目的探讨生长抑素受体（somatostatin receptor，SSTR）1～3亚型蛋白在胃癌发生、发展中的作用及其相关性。方法对病理确诊的47例胃癌组织标本采用免疫组化二步法检测SSTR1～3亚型蛋白的表达。采用Fisher精确概率法分析临床相关因素与上述指标的相关性。结果SSTR1—3亚型蛋白的表达与患者的性别、肿瘤的部位、有无淋巴结转移及临床分期无统计学意义（P〉0．05）；20例浸润型胃癌SSTR1阳性表达率为50．O％，26例溃疡型胃癌中SSTR1阳性表达率为80．77％，两组比较有显著性差异（P〈0．05）；14例高／中分化SSTR2阳性率为71．43％，33例低分化SSTR2阳性率为30．30％，两组比较有显著性差异（P〈0．05）；20例浸润型胃癌SSTR3阳性表达率为30．00％，26例溃疡型胃癌中SSTR3阳性表达率为69．23％，两组比较有显著性差异（P〈0．05）；14例高／中分化SSTR3阳性率为78．57％，33例低分化SSTR3阳性率为42．42％，两组比较有显著性差异（P〈0．05）。结论SSTR1～3亚型可能与胃癌的发生、发展有关，并参与抑制胃癌细胞的增殖。

Objective To study the role of somatostatin receptor （SSTR） subtypes 1 - 3 in the process of genesis, development of gastric carcinoma and their relationship. Methods Two-step immunohistochemical staining was used to examine the expressions of SSTR1 -3 in 47 cases of gastric specimens, then the relationship between them and clinical pathology was analyzed by Fisher test. Results The expressions of SSTR1 - 3 were not related to gender, the location, lymph node metastasis and clinical stage （P 〉0.05） ; the expression rates of SSTR1 and SSTR3 in 20 cases of invaded gastric carcinoma （50. 00% , 30.00% ） were lower than that in 26 cases of ucler gastric carcinoma （80.77% , 69.23% ）（P 〈 0.05）; the expression rates of SSTR2 and SSTR3 in 14 cases of high/middle differentiation degree （71.43%, 78.57% ） were higher than that in 33 cases of low differentiation degree （31.25%, 42.42% ） （ P 〈 0.05 ）. Conclusion SSTR1 - 3 may play an important role in the development and genesis of gastric carcinoma, and it inhibites the proliferation of gastric carcinoma.