胃癌术后早期小肠内滴注芪黄煎剂对胃动素、血管活性肠肽、生长抑素的影响

Effect of Early Intestinal Dripping of Chinese Herbs Qihuang Decoction on MOT and VIP and SS in Patients with Gastric Cancer after Operation

目的:探讨健脾通里中药芪黄煎剂对胃癌手术后胃肠激素胃动素、血管活性肠肽、生长抑素的调节。方法:将30例要行胃癌手术的患者随机分为研究组和对照组。分别观察:两组术后胃动素、血管活性肠肽、生长抑素的变化。结果:两组术后1天胃动素水平均明显降低(P<0.05),术后7天胃动素水平均明显回升,与对照组相比,术后应用中药芪黄煎剂能有效调节术后胃动素的变化(P<0.05);而胃癌患者VIP术前高表达,术后1天血管活性肠肽、生长抑素水平均高于正常水平(P<0.05),术后7天血管活性肠肽、生长抑素水平基本恢复正常,与对照组相比,术后应用中药芪黄煎剂能有效调节术后血管活性肠肽、生长抑素的变化(P<0.05)。结论:胃癌手术后早期应用健脾通里中药芪黄煎剂,有利于调节胃肠激素水平,使之在手术后尽快恢复正常。

Objective： To observe the influence of Early Intestinal Dripping of Chinese Herbs Qihuang decoction on gastrointestinal hormone （Motilin, MOT; Vasoactive intestinal peptide, VIP; Somatostatin, SS） in Patients with Gastric Cancer after Operation. Methods： 30 cases with gastric cancer were randomly divided into two groups, i. e. the studied group （n = 15）, treated with Chinese Herbs Qihuang decoction, and the control group （n = 15） treated with normal saline. The medication was started from the 1 st day after operation by intestinal dripping daily. 7 days as one course. The changes of gastrointestinal hormone （ MOT, VIP, SS） were observed before and after operation. Results： The level of MOT at first day after operation were decreased significantly in both groups （ P 〈 0. 05 ）, while the level of MOT significantly increased at 7th after operation. Compared with control group, the use of herbs Qihuang decoction after operation may effectively modulate the changes of MOT after operation （ P 〈 0. 05） ; patients with gastric cancer had a high expression of VIP before operation and higher level of VIP, SS concentration at first day after operation, while the level of VIP, SS concentration basically recovered at 7th day after operation Compared with control group, the use of herbs after operation may effectively modulate the changes of VIP, SS after operation （P 〈 0. 05） . Conclusions： The early use of Qihuang decoction after gastric cancer operation may regulate the level of MOT, VIP and SS, and enhance its recovery after operation.