可溶性白细胞介素2受体与肝病相关性观察

OBSERVATION ON THE CORRELATION BETWEEN sIL-2R AND LIVER DISEASES

采用双抗体夹心ＥＬＩＳＡ法对慢迁肝（ＣＰＨ）、慢活肝（ＣＡＨ）、肝炎后肝硬化（ＬＣ）、原发性肝癌（ＰＬＣ）４种肝病各４０例的可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）进行测定，同时检测病人的外周血自然杀伤细胞（ＮＫ）活性。结果显示４种肝病病人ｓＩＬ－２Ｒ水平均较正常人高，ＮＫ细胞活性均较正常人低，上述４种肝病中ｓＩＬ－２Ｒ水平依次升高，而ＮＫ细胞活性依次下降，提示ｓＩＬ－２Ｒ与ＮＫ细胞活性密切相关。检测病人ｓＩＬ－２Ｒ水平有助于判断肝病病人病情演变和预后。

The levels of serum soluble interleukin 2 receptor(sIL-2R) and natural killer cell(NK) activity were measured in patients with chronic persistent heapatitis B(CPH),chronic active hepatitis B(CAH),liver cirrhosis (LC) and primary liver cancer(PLC) by sandwich ELISA.40 cases of each liver disease were studied.The results showed that the levels of sIL-2R in these four groups of patients were higher than those of the normal controls,and the levels of sIL-2R in CPH,CAH,LC and PLC increased successively.But NK activity inCPH,CAH,LC and PLC decreased successively.Those results suggest that there is a close relationship between the levels of sIL-2R and NK activity.sIL-2R detemination aids in assessing the progress and prognosis of liver diseases.