枇杷叶中三萜类化学成分的研究

Studies on the Triterpenes from Loquat leaf(Eriobotrya japonica)

目的:研究枇杷叶的化学成分。方法:采用硅胶、ODS柱、制备薄层及制备液相法分离枇杷叶中的化学成分,运用化学和有机波谱分析方法确定化合物结构。结果:从枇杷叶中分离得到9个三萜类化合物,经鉴定分别为白桦脂酸甲酯(Ⅰ)、齐墩果酸(Ⅱ)、乌苏酸(Ⅲ)、2α-羟基齐墩果酸甲酯(Ⅳ)、科罗索酸甲酯(Ⅴ)、2α-羟基齐墩果酸(Ⅵ)、科罗索酸(Ⅶ)、委陵菜酸(Ⅷ)、蔷薇酸(Ⅸ)。结论:化合物Ⅰ、Ⅴ为首次从该植物及该属植物中分离得到。

Objective： To investigate the chemical constituents from Loquat leaf （Eriobotrya japonica）. Methods：Compounds were isolated by a combination of silica gel and ODS column chromatographies and preparative TLC and HPLC, their structures were identified by chemical and spectral methods. Results ： Nine triterpenes were isolated and identified as methyl betuliate （ Ⅰ ）, oleanolic acid （ Ⅱ ） ,ursolic acid （ Ⅲ） . methyl maslinate （ Ⅳ） , methyl eorosolate, （ methyl 2α-3α-dihydroxyurs-12-en-28-oate, Ⅴ ） , maslinie acid （ Ⅵ ） ,corosolic acid（ Ⅶ ） ,tormentie acid（Ⅷ） ,euseaphic acid （Ⅸ）from loquat leaf. Conclusion：Compounds Ⅰ and Ⅴ are obtained from this plant and Eriobotrra genus for the first time.