双呋喃二氢沉香呋喃醚类衍生物的合成及其杀虫活性

Synthesis and Insecticidal Activity of the Ether Analogues of Dihydroagarofuran

以苦皮藤Celastrus angulatus Max．提取物水解产物中的1β，2β，4α，6α，8β，9α，12-七羟基-β-二氢沉香呋喃为起始原料，与甲磺酰氯（MsCl）反应后，得到一结构新颖的双呋喃二氢沉香呋喃甲磺酸酯（Ⅱ），并设计合成了8个新的双呋喃二氢沉香呋喃醚类衍生物2．1—2．8，其结构经核磁共振谱、质谱等方法鉴定。初步的杀虫活性测定结果表明：化合物2．1—2．8对粘虫Mythimna separata3龄幼虫具有较强的胃毒活性，其中烯丙基醚和正丁基醚衍生物（2．5和2．6）在20mg／mL的浓度下对粘虫3龄幼虫的校正死亡率分别为66．7％和50．0％。

4α, 6α-bihydroxy-8α, 9α-epoxy-1β-methylsulfony-2β, 12-ether was obtained by methylsulfonylation from 1β,2β,4α ,6α, 8β,9α, 12-hepthydroxy-β-dihydroagarofuran, a hydrolysis product of crude extract from Celastrus angulatus Max. and eight new β-dihydroagarofuran ether analogues were synthesized using 4α, 6α-bihydroxy-8,9-epoxy-1β-methyl-sulfony-2β, 12-ether-β-dihydroagarofuran as starting material. The structures of these compounds were compounds by NMR and MS spectral data. The preliminary bioassay results showed that compound 2.1- 2.8 exhibited stomach toxicity against the third instar larvae of Mythimna separata and the mortality from derivative of allyl and n-butyl ether reached 66.7% and 50.0% ,respectively at theconcentration of 20 mg/mL.