早期乳腺癌保乳治疗与乳腺癌改良根治术近期临床对比

Comparison of short-term curative effect between breast-conserving and radical operation for early-stage breast cancer

目的探讨乳腺癌保乳手术加综合治疗的适应证、治疗方法和疗效。方法对2005年12月至2007年11月本院开展的21例行保乳手术加综合治疗病例(保乳组)和28例行改良根治术加综合治疗(对照组)的乳腺癌病例进行对比分析。结果保乳组21例双侧乳房乳头基本对称、外形良好。保乳组、对照组的平均手术时间分别为170.3±20.1 min和200.6±25.6 min,术中平均出血量分别为289±31 ml和410±23 ml,手术并发症发生率分别为14.3%和32.1%,保乳组均优于对照组(均P<0.05)。近期随访显示,两组患者总的局部复发率比较,差异无显著性(P>0.05)。结论临床早期乳腺癌采用保乳手术加综合治疗可以取得满意的临床疗效,早期乳腺癌可以行保乳治疗。

Objective To investigate the approach,indication and therapeutic effect of breast conserving operation. Methods The clinical data of 49 cases of early - stage breast cancer in the period of December 2005 to November 2007were retrospectively reviewed and analyzed. Among them, 21 cases received breast - conserving therapy, and the remaining 28 cases received radical operation. Results In 21 cases received breast - conserving therapy, the nipples of two breasts are symmetry and the shape of breast is well on the whole. The mean durations of operation in these two groups were 170.3 ± 20.1 rain and 200.6 ± 25.6 min respectively and the amounts of mean blood loss were 289 ± 31 ml and 410 ±23 ml respectively. The incidence rates of complications were 14.3% and 32.1% respectively. The efficacy of patients in breast - conserving group is superior to that of patients in radical group（ P 〈 0.05 ）. Conclusion Satisfactory clinical effect can be achieved by breast - conserving therapy for patients with early - stage breast cancer.