新生儿窒息早期苯巴比妥与甘露醇联用干预缺氧缺血性脑病疗效观察

Observation of curative effect of combination application of phenobarbital with mannitol on neonatal asphyxia:early intervention for the prevention of hypoxic-ischemic encephalopathy

目的苯巴比妥与甘露醇联合应用对新生儿窒息进行早期干预治疗预防或减轻新生儿缺氧缺血性脑病(H IE)的疗效观察。方法对44例新生儿窒息病儿在常规治疗基础上联合应用苯巴比妥和甘露醇(干预组)与40例常规治疗(对照组)的新生儿窒息病儿进行对照比较预后。结果干预组重度H IE发生率明显低于对照组(P(0.05)。结论联合早期应用苯巴比妥与甘露醇能起到保护脑细胞的作用,预防和减轻脑损伤的发生,能有效地改善缺氧缺血性脑病的预后。

Objective To observe the curative effect of the combination application of phenobarbital with mannitol on neonatal asphyxia in order to prevent neonatal hypoxic - ischemic encephalopathy （HIE）. Methods The prognosis was compared between 44 neonatal asphyxia cases underwent conventional treatment combined with treatment of phenobarbital and mannitol and 40 neonatal asphyxia cases underwent conventional therapy only. Results The incidence rate of severe HIE in phenobarbital and mannitnl - based intervention group was significantly lower than that in the control group （ P 〈 0.05 ）. Conclusion The early application of combined phenobarbital and mannitol may protect brain cells and effectively improve the prognosis of hypoxie - ischemic encephalopathy.