侧脑室注射环丙沙星对大鼠脑电、脑电功率谱及频率分配的影响

Effect of intracerebroventricular in jection of ciprofloxacin ondlectric activity,power spectrum and frequency distribution in rats

以不同剂量的环丙沙星（３皿ｕｇ·Ｋｇ－１及６００ｕｇｋｇ－１）注入大鼠右侧脑室后，于皮层感觉运动区记录皮层脑电图作脑电功率谱及频率分配分析。注射后两剂量组皮层均先后出现痫样放电（大剂量、小剂量组潜伏期分别为３５．３３±３５．１６和１５３．８８±９４．２１９）脑电功率谱及频率分配分析主要表现为总功率及脑电的快成分（ａ、β和β２）所占百分比增加而功率主峰频段δ波所占百分比减少。提示：环丙沙星对中枢神经系统具有兴奋作用。

Electrocorticogram (ECOG) was recorded and analysed in sensorimotor area of rat cortex, by using power spectrum analysis tecchnique, after 300ug . kg-1 and 600ug . kg-1 Ciprofloxacin (CPLX) injected into right ventricle of , brain. The epileptiform discharge appeared at 35,33±35.16 sec and 153.88±94.21 sec in large - dose and small dose - group respectively. The total power and power percentage of . x and band increased, while those of the band with the peak of the main power ( band ) decreased . These results suggest that CPLX can increase excitability of CNS.