化学性胆囊切除术实验研究

Experimental studies on chemical cholecystectomy dept of surgery, college of clinical medicine

本文用１００％酒精及１００％酒裕加３．５％石炭酸在结扎闭塞胆囊管（ＣＤ）的基础上硬化家兔的胆囊粘膜，于２周、４周、６周等不同时相观察胆囊组织的形态变化。测量其纤维组织的体密度（Ｖｖ％）及厚度。发现与对照组有显著差异，观察了硬化剂对其他组织的作用，讨论了硬化胆囊的效果、硬化剂的选择、对残留或再生上皮的处理及阻管技术。认为化学性胆囊切除术在治疗胆囊结石和防止结石复发方面是可行的。

The experiment was to investigate effects of sclerosing agents as 100% ethanol and 100 % ethanol plus 3.5 % carbolic acid to gallbladders under the occlusion of cystic duct. The histological changes of the gallbladder wall, the degree of fibrosis on the different time phases, the volume density of fibrous tissue in the gallbladder wall. and the remain or regeneration of epithelium were discussed. The results ahowed that there was obvious proliforation in fibrous tissue instead of the gallbladder epithelium after 2 weeks, and the gallbladders were all fibrotic after 6 weeks. The experiment suggests that the chemical cholecystectomy is a possible way for chronic cholecystitis and cholecyatolilhiesis in appropriate cases.