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环丙沙星和头孢哌酮透入人胰腺的研究

Penetration of Ciproloxacin and Cefoperazone into Human Pancreas
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摘要 抗菌药物在继发胰腺感染的防治中具有十分重要的地位,其疗效决定于抗菌药物能否在胰腺达到治疗浓度。该研究通过对10例胰十二指肠切除患者术中切除的胰组织和术后胰管内置管获得的纯胰液,用高效液相色谱法分别测定环丙沙星和头孢哌酮在血清、胰组织及胰液中的浓度。结果显示:环丙沙星和头孢哌酮的平均胰液渗透率分别是44%和17%,两药在胰腺中的浓度均在大多数胰腺感染致病菌的MIC-90以上。 Major pancreatic infection is responsible for more than 80% of deaths in patients with acute pancreatitis. Therefore, the role of antimicrobial drugs in the prevention and treatment of secondary parcreatic infection is very important. The choice of antimicrobial drugs must be based upon the ability of the drug to exceed the therapeutic concentration in pancreas for the common pathogens. The penetration of ciprofloxacin and cefoperazone into pancreas was investigated in ten patients who had undergone pancreatoduodenectomy. The pancreatic juice was temporarily diverted to the exterior via a pancreatic duct catheter. The pancreatic tissue was obtained intraoperatively and pancreatic juice was drained postoperatively. The antimicrobial drug concentrations were determined by highperformance liquid chromatography. The concentrations of ciprofloxacin and cefoperazone in pancreatic juice were 44% and 17%, respectively, of those in serum, and exceeded the in vitro concentration (MIC90) for most bacteria associated with pancreatic infections. The result indicates that ciprofloxacin and cefoprazone appear to be appropriate for both prophylaxis and therapy of secondary pancreatic infections.
出处 《华西医科大学学报》 CSCD 1997年第4期365-368,共4页 Journal of West China University of Medical Sciences
基金 四川省卫生厅科研基金
关键词 环丙沙星 头孢哌酮 渗透率 急性 胰腺炎 Ciprofloxacin Cefoperazone Concentration of drugs Penetration rate Acutepancreatitis
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