红霉素胸膜腔粘连对恶性胸腔积液的治疗价值

The Value of Erythromycin Pleurodesis in the Treatment of Malignant Pleural Effusions

为评价红霉素作为胸膜粘连剂的价值，对２６例恶性胸腔积液患者采用红霉素１ｇ溶于５％葡萄糖３０ｍｌ中注入胸膜腔内，进行胸膜腔粘连治疗。结果显示：应用红霉素后１５例患者出现明显的胸膜粘连，７例患者胸腔积液明显减少，４例无效，治疗的总有效率为８４．６％，未见明显不良反应。红霉素的胸膜粘连作用可能为产生局部化学性炎症所致。

Malignant pleural effusion is a frequent complication of patients with advanced malignant tumors.For many patients suffering from malignant pleural effusion that increases rapidly and may be life threatening,it is important to control the effusions.To investigate the value of erythromycin as a pleural sclerosant,a dose of l g erythromycin in 30ml of 5% glucose was injected into the pleural cavity of 26 patients with malignant pleural effusion.The results were assessed by Millers standards.After treatment,numerous adhesions were present in 15 cases;Pleural effusion reduced in 7 patients,and no effect was noted in 4 patients.The total response rate was 84.6%, and there were no severe sideeffects.The erythromycininduced pleurodesis is probably the result of induced chemical inflammation in the locality.This study suggests that erythromycin is a useful pleural sclerosant.