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血管内皮生长因子在脑胶质瘤中自分泌研究 被引量：2

Autocrine of vascular endothelial growth factor in glioma
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摘要 目的观察血管内皮生长因子（VEGF）在脑胶质瘤中自分泌现象。方法采用免疫组织化学及图像分析方法，检测74例脑胶质瘤中肿瘤细胞上血管内皮生长因子受体VEGFRl和VEGFR2的表达，取其中42例检测VEGF的表达的情况。结果VEGF在胶质瘤中表达强度与肿瘤病理级别明显相关（P〈0．05，r=0．331）；VEGFR1、2在胶质瘤瘤细胞中表达强度吸光值分别为：正常组织（0．2104±0．0297）和（0．2100±0．0257）；WHOI（0．2328±0．0194）和（0．2324±0．0186）；WHOⅡ级（0．2533±0．0155）和（0．2514±0．0147）；WHOⅢ级（0．2709±0．0203）和（0．2720±0．0149）；WHOⅣ级（0．2906±0．0282）和（0．2834±0．0285）；表达强度与胶质瘤病理级别明显相关（P〈0．01，r=0．748；P〈0．01，r=0．754）。结论在脑胶质瘤中存在VEGF的旁分泌和自分泌现象，并与病理级别有关。 Objective To determine the autocrine phenomenon of vascular endothelial growth factor （VEGF） in glioma. Methods Immunohistochemistry （IHC） was used to detect the expression of VEGF,VEGF receptors （VEGFR1/VEGFR2） in brain glioma. The expression of VEGFR1 and VEGFR2 was measured by image analysis system. Results The absorption values of VEGFRI ,2 in glioma tissues were （0.2104 ±0. 0297） and （ 0, 2100 ±0, 0257） ; WHO I （0.2328 ± 0. 0194） and （0. 2324 ± 0.0186）;WHOⅡ （0.2533±0.0155） and （0.2514±0.0147）;WHO Ⅲ （0.2709±0.0203） and （0. 2720±0.0149） ; WHO IV （ 0. 2906 ±0. 0282） and （ 0. 2834±0. 0285 ）. The expression of VEGF, VEGFR1 and VEGFR2 protein was correlated significantly with glioma histological grade （ P 〈 0.05, r = 0.331;P〈0.01 ,r=0.748;P〈0.01 ,r =0.754）. Conchtsion This study suggests that there are VEGF paracrine and autocrine phenomena in brain glioma.
作者 周爱萍 谭淑莲 林志雄 李承
机构地区 福建医科大学附属第一医院神经外科
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2008年第10期1287-1288,共2页 Chinese Journal of Experimental Surgery
基金 福建省自然科学基金资助项目（C0540013） 福建省教育厅资助项目（JR05241）
关键词 胶质瘤 自分泌 血管内皮生长因子 Glioma Autocrine Vasctdar endothelial growth factor
分类号 R739.4 [医药卫生—肿瘤]
  • 相关文献

参考文献6

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二级参考文献11

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共引文献11

同被引文献10

  • 1Guo P, Xu L, Pan S, et al. Vascular endothelial growth factor isoforms display distinct activities in promoting tumor angiogenesis at different anatomic sites. Cancer Rcs,2001,61:8569-8577.
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  • 10宇洋,李聪,张晶,孙岩,孙世波.星形细胞上调基因-1和血管内皮生长因子在胆管癌组织中的表达及其临床意义[J].中华实验外科杂志,2013,30(3):624-626. 被引量：2

引证文献2

二级引证文献5

中华实验外科杂志
2008年 第10期

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