混合淋巴细胞反应中白细胞介素-2和肿瘤坏死因子-α的表达对肝移植急性排斥反应的预测价值
摘要
白细胞介素(IL)-2和肿瘤坏死因子(TNF)-α的表达水平与器官移植供受体间主要组织相容复合体(MHC)的吻合度密切相关。动物实验叫和临床病例中,移植物受体术后血浆IL-2或TNF-α浓度升高提示急性排斥反应(AR)的发生。淋巴细胞激活是肝脏移植AR的首要因素,供受体淋巴细胞混合反应(MLR)是研究移植排斥反应机制的可靠模型。
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2008年第10期1343-1343,共1页
Chinese Journal of Experimental Surgery
参考文献8
-
1Ormonde DG, De BW, Kierath A, et al. Banff schema for grading liver allograft rejection: utility in clinical practice. Liver Transpl Surg, 1999,5:261-268.
-
2司忠义,王中彬,谷春久.同种异体心脏移植中供体特异输注对肿瘤坏死因子-α的影响[J].中华实验外科杂志,2003,20(11):1007-1008. 被引量:1
-
3叶文学,沈振亚,于曙东,余云生,焦鹏.胸腺修饰诱导大鼠心脏移植耐受与白细胞介素-2,10的关系[J].中华实验外科杂志,2006,23(3):309-311. 被引量:5
-
4张雷,朱彤,郭晖,艾建华,闵志廉,朱有华,陈忠华.FTY720,40-氧-(2-羟乙基)-雷帕霉素和环孢素A延长小鼠心脏移植物存活时间的对比研究[J].中华实验外科杂志,2004,21(8):966-967. 被引量:8
-
5Warle MC, Metselaar HJ, Hop WC, et al. Cytokine gene polymorphisms and acute liver graft rejection:a meta-analysis. Liver Transpl,2005,11 : 19-26.
-
6Kishi Y,Sugawara Y,Tamura S,et al. Histologic eosinophilia as an aid to diagnose a-cute cellular rejection after living donor liver transplantation. Clin Transplant, 2007, 21:214-218.
-
7付必莽,唐浩然,张捷,张冰.淋巴因子在混合淋巴细胞培养中的表达与肝移植免疫反应[J].中华肝胆外科杂志,2006,12(9):646-648. 被引量:2
-
8Takahashi HK, Iwagaki H, Hamano R, et al. The immunosuppressive effects of nicotine during human mixed lymphocyte reaction. Eur J Pharmacol,2007 ,559 :69-74.
二级参考文献23
-
1Ming-QingXu,Yu-PingSuo,Jian-PingGong,Ming-ManZhang,lu-NanYan.Prolongation of liver allograft survival by dendritic cells modified with NF_(-k)B decoy oligodeoxynucleotides[J].World Journal of Gastroenterology,2004,10(16):2361-2368. 被引量:9
-
2Ahmed SM, Baslam G, Gottmann KD, et al. The effect of transfusion with donor-specific peripheral lymphocytes, whole blood or erythrocytes on cardiac allografts survival in cyclosporine-treated rats. Transplantation, 1994, 57:634-637.
-
3Shittu EA, Yang CP, Roberts IS, et al. Inhibition of chronic vascular rejection by donor-specific blood transfusion is associated with a reduction in transforming growth factor-beta1 expression. Transplantation, 2002,27:1573-1581.
-
4Brunson ME, Tchervenkov JI, Alexander JW. Enhancement of allograft survival by donor-specific transfusion one day prior to transplant. Important of timing and specificity when DST is given with cyclosporine.Transplantation, 1991,52: 545-549.
-
5Alvarez CM, Fernandez D, Builes M, et al. Intragraft cytokine expression in heart transplants with mild or no histological rejection. Clin Transplant, 2001, 15:228-235.
-
6Tsui TY, Jager MD, Deiwick A, et al. Delayed lie-level calcineurin inhibition promotes allospecific tolerance induction by posttransplantation donor leukocyte infusion. Transplantation, 2002, 73:1325-1332.
-
7Josien R, Miischen M, Gilbert E, et al. Fas ligard, tumor necrosis factor-α expression, and apoptosis during allograft rejection and tolerance.Transplantation, 1998, 66: 887-893.
-
8Semiltova N,Shen XD,Fishbein MC,et al.Posttransplant administration of allochimeric major histocompatibility complex class-Ⅰ-molecules induces true transplantation tolerance.Transplantation,2003,75:550-553.
-
9Sebille F,Brouard S,Petzoud T,et al.Tolerance induction in rats,using a combination of anti-CD154 and donor splenocytes,given once on the day of transplantation.Transplantation,2003,75:169-172.
-
10Sayegh MH,Perico N,Imberti O,et al.Thymic recognition of class 11 major histocompatibility complex allopeptide induces donor-specific unresponsiveness to renal allografts.Transplantation,1993,56:461-465
共引文献12
-
1曹杨,陆晓峰,韩成龙,张信英.大鼠异体肢体移植后存活时间与FK506和FTY720的联合免疫抑制作用[J].中国临床康复,2005,9(22):103-105. 被引量:4
-
2张善中,谭建明,唐孝达.血管化小鼠异位心脏移植模型[J].中华实验外科杂志,2006,23(10):1276-1276. 被引量:4
-
3张旭东,郭树忠,李荟元,王大太.雷帕霉素局部用药在异体复合组织移植中的应用[J].中华实验外科杂志,2007,24(3):370-370. 被引量:5
-
4高明明,高向东,顾觉奋.新型免疫抑制剂FTY720的研究进展[J].国外医药(抗生素分册),2007,28(5):215-218. 被引量:5
-
5李刚,李燕军,安鑫,赵浩亮.FTY720在同种肝细胞移植大鼠中的免疫抑制作用[J].中国药物与临床,2008,8(7):544-546. 被引量:5
-
6孟庆刚,孙丕云,岳伟杰,胡成乙,王立群.胸腺修饰诱导同种异体静脉移植的免疫耐受研究[J].中华实验外科杂志,2009,26(7):895-897. 被引量:1
-
7崔广晖,赵松,廖崇先,马启明,王具明,夏宗江.转化生长因子-β1转基因联合FTY720对大鼠心脏移植物缺血-再灌注损伤的影响[J].中华实验外科杂志,2009(11):1413-1415.
-
8郝胜华,黄文鹏,黄祖发.淋巴细胞P-gp表达水平对他克莫司免疫抑制作用的影响[J].中华实验外科杂志,2009,26(12):1623-1624.
-
9王默,吴树明,唐慧,庞昕焱,金星,吴学君.大鼠移植心脏心肌内心电图描记模型的建立[J].中华实验外科杂志,2010(12):1940-1942. 被引量:1
-
10李丽,胡为民,王朝莉,杨致邦.小鼠B7-H4基因的真核表达及其对淋巴细胞增殖的影响[J].中国微生态学杂志,2012,24(4):292-294. 被引量:3
-
1郎韧,李宁,杨翔,贺强,高居忠.血清sIL-2R、IL-6及胆汁IL-6监测对早期预测肝移植急性排斥反应的作用[J].腹部外科,2004,17(6):327-329. 被引量:1
-
2甘秋枝,胡惠英.自体血液回收对全髋关节置换术患者炎性因子和凝血功能的影响[J].山西医药杂志(上半月),2013,42(2):166-168. 被引量:3
-
3蔡青,韩星海,陈蕊雯,杨波,闾坚强.强直性脊柱炎与HLA-B和HLA-DRB1的相关性研究[J].中华医学杂志,2005,85(14):992-994. 被引量:7
-
4赵蓓,孙若星,曹祥山,华晓莹,钱新瑜,周民,孙剑.伴有抑郁障碍的恶性血液病患者抗抑郁治疗前后细胞免疫及细胞因子的变化[J].精神医学杂志,2009,22(6):409-411. 被引量:7
-
5彭周全,张卫,李丽伟.股神经阻滞对全身麻醉下全膝置换患者炎性反应的影响[J].中华实验外科杂志,2014,31(12):2789-2789. 被引量:2
-
6孙玮,刘秀梅.B7-H1在类风湿关节炎患者血清中的水平及相关性分析[J].中国药物与临床,2009,9(8):699-701. 被引量:1
-
7林民专,赵明.基因治疗与器官移植研究近况[J].国外医学(外科学分册),1998,25(6):322-324.
-
8王洁,周兴根,曹辉,万智钢,李金彪.围术期静脉输注利多卡因对腹腔镜胆囊手术患者炎症因子的影响[J].山西医药杂志,2015,44(19):2265-2267. 被引量:9
-
9樊华,陈大志,贺强,郎韧,李立新,韩东冬,寇建涛,金中奎,秦建民.外周血T淋巴细胞亚群变化能预测肝移植急性排斥反应吗?[J].肝胆外科杂志,2010,18(3):177-179. 被引量:5
-
10罗说明,林健,周智广.IFIHl基因多态性与自身免疫性疾病[J].中华医学杂志,2012,92(21):1505-1507.