急性胆源性胰腺炎患者血清NO、SOD、CAT的变化及其临床意义

The changes and clinical significance of serum nitric oxide,superoxide dismutase,catalase in acute biliary pancreatitis

目的:对比研究血清一氧化氮(NO)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)在急性胆源性胰腺炎(ABP)和正常对照组之间的差别,以探讨各指标的意义。方法:随机选择临床ABP患者40例,分为轻症ABP(MABP)与重症ABP(SABP)二型,门诊健康体检者50例作为对照,分别检测血清NO、SOD、CAT的浓度。结果:ABP患者血清NO和CAT浓度比对照组明显升高(P<0.01),且SABP比MABP升高更明显(P<0.01)。SOD比对照组明显降低(P<0.01),且SABP下降更明显(P<0.05)。结论:NO和CAT参与了ABP的发病,且与ABP的病情呈正相关。SOD在ABP组随病情加重而下降,提供外源性SOD可能可以减轻ABP的病情。

Objective：Contrasting serum nitric oxide, superoxide dismutase catalase and between the acute biliary pancreatitis group and the normal group,to discuss the significance of each index. Methods：Forty clinical acute biliary pancreatitis patients were selected randomly and divide into two types （mild ABP and severe ABP）, 50 policlinic medical examination people were selected as the comparison, serum NO, SOD and CAT levels were examined in every object respectively. Results：Serum NO and CAT levels in ABP patients were higher than those in normal people（P 〈 0.01 ） and elevated remarkably in SABP（P 〈 0.01 ）. While serum SOD in ABP patients was lower than that in normal people （P 〈 0.01 ） and descended remarkably in SABP （P 〈 0.05）. Conclusion： NO and CAT participated in ABP development, whose levels were parallel to ABP status. SOD descended according to ABP status, providing that extrinsic SOD might alleviate the severity of ABP.