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环氧合酶-2基因多态性与膀胱癌的易感性 被引量：1

Association study of cyclooxygenase 2 polymorphisms and bladder cancer
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摘要 目的探讨环氧合酶2（COX-2）基因多态性与膀胱癌易感性的关系。方法采用病例对照研究方法，以聚合酶链反应限制性片段长度多态性技术（PCR—RFLP）及错配聚合酶链反应-限制性片段长度多态性技术（PIRA-PCR）分别检测180例膀胱癌患者和180例非肿瘤患者COX-2基因-765G／C、-1195G／A和-8473T／C3个多态位点，采用X2检验比较不同基因型与膀胱癌风险的关系。结果膀胱癌组和对照组COX-2—765G／C及1195G／A2个位点的3种基因型频率分布差异无统计学意义（P=0．582，P=0．270）；2组间COX-2—8473T／C位点的3种基因型分布差异有统计学意义（P=0．041），携带突变等位基因C的个体（-8473TC＋CC）患膀胱癌的风险显著降低（OR=0．56，95％CI=0．35～0.88）。结论COX-2—765G／C以及-1195G／A可能与膀胱癌易感性无关，COX-2—8473T／C与膀胱癌易感性相关。 Objective To study the relationship between cyclooxygenase 2 （COX-2） polymorphisrns and the susceptibility of bladder cancer. Methods Polyrnerase chain reaction-restricted fragments length polyrnorphisrn （PCR-RFLP） and the primer-introduced restriction analysis （PIRA-PCR） assay were used to genotype the COX-2 -765G/C, 1195G/A and -8473T/C polyrnorphisrns in a casecontrol study of 180 bladder cancer cases and 180 cance-free controls in a Chinese population. Results The distribution of the genotype frequencies of -765G/C and -1195G/A were not statistically different between the cases and controls （P：0. 582 for -765G/C and P=0. 270 for -1195G/A）. Polymorphisms of COX-2 -8473T/C were associated with the susceptibility to bladder cancer. The individ uals with the 8473C allele had a decreased risk of bladder cancer （OR=0.56, 95%CI=0. 35-0. 88）. Conclusions Polymorphisrns of COX-2 -765G/C and -1195G/A are not associated with the susceptibility to bladder cancer. However, COX-2 -8473T/C can reduce the risk of bladder cancer.
作者 宋东奎 陈昆 李中学 李梁斌 杨小明 刘建 张莉蓉
机构地区 郑州大学第一附属医院泌尿外科郑州大学肿瘤分子外科研究所 郑州大学基础医学院药理学教研室
出处 《中华泌尿外科杂志》 CAS CSCD 北大核心 2008年第10期704-707,共4页 Chinese Journal of Urology
基金 河南省科技厅重点攻关项目（72102310106）
关键词 膀胱肿瘤 癌 环氧合酶-2 基因多态性 Bladder neoplasms Carcinoma Cyclooxygenase-2 Genetic polymorphisms
分类号 R737.14 [医药卫生—肿瘤]
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参考文献11

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二级参考文献31

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共引文献14

同被引文献16

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中华泌尿外科杂志
2008年 第10期

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