血管紧张素Ⅱ1型受体基因多态性与肾病综合征的关系

Relationship between A1166C gene polymorphism of angiotensin Ⅱ type 1 receptor and primary nephrotic syndrome

目的:探讨血管紧张素Ⅱ1型受体(AT1R) A1166C基因多态性与原发性肾病综合征的关系。方法:选取原发性肾病综合征患者46例为肾病组,健康体检者52例为对照组;采用聚合酶链反应-限制性核酸内切酶片段长度多肽性技术分析肾病组与对照组的AT1R A1166C基因型和基因分布频率。结果:在肾病组和对照组中均以AA型最常见,CC型未发现,两组的AT1R基因频率分布差异无显著性;在肾病组中比较不同AT1R基因型的生化结果,差异亦无显著性;表现为膜性肾病、局灶性节段性肾小球硬化等肾脏病变重的患者是以AC基因型多见,差异有显著性。结论:AT1R基因多态性与原发性肾病综合征的发生无明确关联,但可能与原发性肾病综合征的进展及预后有关。

Objective To explore the association of A1166C gene polymorphism of angiotensin II type 1 receptor （AT1R） with primary nephrotic syndrome. Methods The types and distribution of A1166C gene were examined in 46 patients with primary nephrotic syndrome and in 52 healthy controls by polymerase chain reaction-restriction fragment length polymorphism. Results In the group with nephrotic syndrome and the control group, AA genotype was the most common type and CC genotype was undetectable, with no significant differences in the frequency of the genotypes. The biochemical results did not differ significantly among the genotypes in the group with nephrotic syndrome. AC genotype was more frequent in patients with membranous nephropathy or focal segmental glomerulosclerosis （P 〈 0.01 ）. Conclusion The gene polymorphism of ATIR is not associated with the genesis of primary nephretic syndrome but may be involved in the progression and prognosis of primary nephrotic syndrome.