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急性白血病骨髓血管新生与Bcl-2蛋白关系的研究进展 被引量：1

Relationship between Angiogenesis and Bcl-2 in Acute Leukemia
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摘要 目的探讨急性白血病骨髓血管新生与Bcl-2的关系,为白血病的治疗寻找新的治疗方法。方法查阅总结近20年来国内外相关文献,对血管新生与急性白血病的关系、Bcl-2与白血病的关系及VEGF与Bcl-2的关系进行综述。结果白血病细胞表达较高的VEGF,VEGF促使血管生成和内皮细胞增生,VEGF能上调Bcl-2的表达,Bcl-2在血管生成过程中高表达,白血病细胞与骨髓新生血管之间存在密切的关系。结论抑制Bcl-2的表达,控制骨髓血管生成,为今后白血病治疗打下基础。 Objective To explore the relationship between angiogenesis and Bcl-2 in acute leukemia in order to find a new therapy to acute leukemia. Methods Research and analyze the literature on angiogenesis and acute leukemia, Bcl-2 and leukemia and VEGF and Bcl-2 in the past 20 years. Results Acute leukemia cells express high level VEGF. VEGF improves the angiogenesis and endothelial cells growth. VEGF improves expression of Bcl-2,Bcl-2 make high expression on the process of angiogenesis. There is a close relationship between leukemia cells and angiogenesis in bone marrow. Conclusion Anti- Bcl-2 and anti- angiogenesis therapy provide fundment to treat leukemia.
作者 陈宝伶 李永萍
机构地区 大理学院附属医院血液肿瘤科
出处 《中国现代医生》 2008年第26期29-30,34,共3页 China Modern Doctor
关键词 白血病 血管新生 血管内皮生长因子 BCL-2 Leukemia Angiogenesis Vascular endothelial growth factor Bcl-2
分类号 R733.71 [医药卫生—肿瘤]
  • 相关文献

参考文献20

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二级参考文献25

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共引文献10

同被引文献18

  • 1贺其图,赵晓华,贾国荣,马宏杰,李静,李喆,刘学文,云雁.白血病患者骨髓血管新生与Bcl-2蛋白关系的研究[J].实用癌症杂志,2006,21(4):376-378. 被引量：9
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二级引证文献1

中国现代医生
2008年 第26期

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