沐舒坦联合纳洛酮治疗胎粪吸入综合征74例临床观察

Evaluation for Effect of Mucosolvan in Combination with Naloxone on Meconium Aspiration Syndrome

目的观察沐舒坦、纳洛酮联合治疗胎粪吸入综合征的疗效。方法自2003年1月～2007年1月在我科就诊的胎粪吸入综合征74例,随机分为治疗组40例和对照组34例。两组均给予常规治疗,治疗组在常规治疗基础上加用沐舒坦、纳洛酮,其中沐舒坦每次7.5mg/kg,q6h1次;纳洛酮针首次负荷量0.1mg/kg静推,1h后按0.01mg(/kg·h)的速度经微量输液泵持续静脉注射,每日总量不超过0.4mg/kg。结果在治疗结束时,治疗组显效27例(67.5%),有效11例(27.5%),总有效率为95.0%(38/40);对照组显效15例(44.1%),有效10例(29.4%),总有效率为73.5%(25/34)。两组显效率比较差异有显著性意义(χ2=4.09,P<0.05),总有效率比较差异有非常显著性意义(χ2=6.69,P<0.01)。结论沐舒坦联合纳洛酮治疗胎粪吸入综合征疗效显著,值得临床进一步研究。

Objective To evaluate the effect of mucosolvan in combination with naloxone on meconium aspiration syndrome（MAS）. Methods Seventy-four patients with MAS in our department from January 2003 to January 2007, were divided randomly into control grnup（n=34） and treatment group（n=40）. All patients were treated by conventional therapy,and treatment group were given combined with mucosolvan and naloxone, and mucosolvan（7.5mg/kg） was given every six hour; naloxone（0.1mg/kg） was injected into the bloodstream for the first time,after an hour was given at the stable rate of 0.01mg/kg an hour by microtransfuseon system[total≤0.4mg/（kg· d）]. Results At the end of the course,27 newborns in the treatment group had remarkable effect with the rate of 67.5%（27/40）, ll cases had effect with the rate of 27.5%（11/40）, the total rate was 95.0%（38/40）. And 15 cases in the control group had remarkable effect with the rate of 44.1%（15/34）, 10 cases had effect with the rate of 29.4%（10/34）, the total rate was 73.5%（25/34）. There was significant difference between the two groups in the remarkable rate,and very significant difference between the two groups in the remarkable. Conclusion There are a significant curative effect of the patients with MAS after given mucosolvan and naloxone,and worth further investigating.