胸腺瘤与胸腺瘤合并重症肌无力的临床分析

Clinical Analysis on Thymomas and Thymomas with Myasthenia Gravis

目的:探讨胸腺瘤(TT)及胸腺瘤合并重症肌无力(TTMG)的临床特点。方法:对16年间外科治疗的TT129例,其中单纯TT84例(组1),TTMG45例(组2)的临床特点进行对比分析。结果:组1平均年龄36.6岁,最小年龄4岁,90.4%的病人肿瘤直径大于5cm,病理分期多为III、IV期(66.2%)。组2平均年龄45.2岁,最小年龄20岁,肿瘤直径3cm和5cm以下分别占34.6%和65.6%,55.2%为病理I期。结论:早期胸腺瘤诊断标准为:肿瘤直径<3cm和病理分期I期;TTMG的特征是肌无力(MG)的症状重、病史短、症状进展快、胸腺危象的发生率高。

Objective： To present the clinical experience in treating thymomas and thymomas with myasthenia gravis （MG）. Methods：Between 1991 to 2007,129 patients with thymoma were surgically treated. 84 cases of thymus tumor （TT,Group Ⅰ ） were compared to 45 cases of thymus tumor with myasthenia gravis （TTMG,Group Ⅱ）. Results： In group Ⅰ, the average age was 36.6 years,the youngest was 4 years old. In 90.4% ,the diameter of tumors was 5cm. 66.2G were in stages Ⅲ and Ⅳ of clinical pathology. In group Ⅱ,the average age was 45.2 with the youngest of 20 years old,the diameter of tumor under 3cm and 5cm was 34.6% and 65.6 %. 55.2% was in stage Ⅰ of clinical pathology. Conclusion： Many cases of thymoma in early stage received early treatment. The diagnostic standards of thymoma in early stage are the diameter of tumor is below 3cmand in stage Ⅰ of elini-cal pathology. （2）The clinical characteristics of TTMG are： short history,the rapid progress, serious MG symptoms,and the high incidence of thymus--crisis.