地塞米松联合维生素C治疗慢性ITP的疗效观察

Observation of the Curative Effect of Flushing Dose Dexamethasone with Vitamin C in Treatment of the Chronic Idiopathic Thrombocytolytic Purpura

目的探讨地塞米松冲击疗法配合维生素C方案对慢性特发性血小板减少性紫癜(ITP)的疗效。方法33例慢性ITP患者均给予大剂量地塞米松冲击疗法治疗,并于停用的第2天起开始应用大剂量维生素C维持8w,于第2、8及16周末比较血小板水平。结果治疗后第2周末患者血小板接近正常,与治疗前比较,P<0.01;治疗至第8周末患者均已恢复正常,但与第2周末比较,P<0.05;治疗至第16周末患者血小板水平较第8周末上升,但两者比较无统计学差异(P>0.05)。结论大剂量地塞米松冲击疗法配合维生素C治疗慢性特发性血小板减少性紫癜具有疗效稳定持续、副作用少等优点。

Objective To observe the curative effect of flushing dose dexamethasone（DXM） with vitamin C（Vit C） to the chronic idiopathic thrombocytolytic purpura. Methods 33 patients were given the flushing dose DXM during the first 4 medicative days and then withdrawal. The Vit C were given from the sixth medieative day and for 8weeks. The blood platelets counts were measured at the end of the 2nd, 8th and 16th week during the medicative time. Results The blood platelets counts were near the nadir of the normal ones at the end of the 2nd week, compared with that of pre-therapy, P 〈 0.01 ; The blood platelets counts were in the normal amplitude at the end of the 8nd week,compared with that of 2nd week,P〈0.05; The blood platelets counts at the end of the 16nd week were more than that of 8nd week,but the differences were insignificant, P 〉 0.05. Conclusion The method of prescribing the flushing dose dexamethasone （DXM） with vitamin C （Vit C）to the chronic thrombocytolytic purpura is proved effective and safe and less side-effect.