胺碘酮与普罗帕酮维持阵发性心房颤动复律后窦性心律的疗效观察

The efficacy of maintaining sinus rhythm in patients with paroxysmal atrial fibrillation between amiodarone and propafenone has been compared

目的:观察、比较口服胺碘酮、普罗帕酮用于阵发性心房颤动复律后维持窦性心律的疗效和安全性。方法:患者85例,分为两组,两组患者复律后,甲组口服胺碘酮,乙组口服普罗帕酮,并随机观察。结果:两组均有复发,均有因副作用停药患者,差异有显著性(P<0.05)。结论:胺碘酮与普罗帕酮在维持阵发性心房颤动患者窦性心律方面均有作用,但都有副作用发生,在维持窦性心律的作用上,胺碘酮优于普罗帕酮,副作用发生使治疗停止的危险性方面,胺碘酮占的比例高。

Objective：To compare the efficacy and safety of maintaining the sinus rhythm in patients with paroxysmal atrial fibrillation （AF）between A miodarone and propafenone. Methods：After conversion,eighty-five patients with paroxysmal atrial fibrillation were randomly divided into two groups;group A with amiodarone, group B with propafenone. Results：AF recurrence in some patients in two groups, some patients investigation had to be stoped because of side-effect in both groups, and there was statistically significant difference between two groups P〈0.05）.Conclusion：Both amiodarone and propafenone were effective in maintaining the sinus rhythm for paroxysmal atrial fibrillation ,Amiodarone more effective,side-effects occur in two groups,Amiodarone more.