摘要
目的:了解类风湿关节炎(RA)患者发病形式、临床特点及对患者社会生活的影响。方法:采用流行病学现况调查的方法,对北京大学人民医院2007年5月~8月门诊就诊的RA患者进行随机现场调查。内容包括患者性别、发病年龄、关节表现、关节外表现、疾病对患者工作及生活的影响。结果:本组181例患者中,男女比例为1∶4.2,女性患者发病年龄41.8±13.4岁,早于男性的51.9±13.8岁。首发关节及病程中受累关节依次为近端指间、腕、掌指、膝、踝、跖趾及肘关节。晨僵时间持续>1h者占43.6%。患者的平均病程为9.5±8.5年,出现关节畸形94例(51.9%)。常见的关节外表现包括发热(30.3%)、类风湿结节(20.4%),并发症有继发干燥综合征(48.5%)、肺间质病变(30.3%)等。有家族史者占14.4%。因本病导致停止工作者占30.6%,病史长、关节畸形及未能在风湿免疫专科诊治为其危险因素。结论:本组RA患者多起病于中青年,患者的女性比例较高,晨僵时间较短,关节外表现常见,畸形的发生率较高,家族性发病者并不少见。患病后近1/3患者停止工作,未及时在风湿免疫专科诊治为其独立危险因素。
Objective:To describe clinical characteristic of rheumatoid arthritis (RA)and its related factors of living disability.Methods:Out patients diagnosed with RA were investigated in the hospital from May to August 2007 ,including sex, age of onset, articular and extra -articular manifestations and disease outcomes.Resuits:In these 181 RA patients,the ratio of male to female was 1:4.2.Onset age of female was younger than male.The affected joints were usually proximal interphalangeal,wrist,metaearpophalangeal etc.Up to 44% patients had morning stiffness time more than 1 hour.The mean history was 9.5±8.5 years.Deformity was observed in 94 (51.9%)patients.Common extra-articular manifestations were fever,rheumatoid nodules,secondary Sjogren's syndrome etc.Proportion of work disability was 30.6% and fatigue was observed in 69.4% patients. Conclusion:In this cohort of RA patients,the sex ratio,onset age and clinical characteristics were different from Caucasian patients.
出处
《中日友好医院学报》
2008年第5期266-269,共4页
Journal of China-Japan Friendship Hospital
基金
国家自然科学基金(30671933)
教育部重点基金(106004)部分资助
关键词
类风湿关节炎
现况调查
关节畸形
rheumatoid arthritis
cross section study
deformity of joint