摘要
目的:系统评价表面增强激光解析电离飞行时间质谱技术(SELDI-TOF-MS)对乳腺癌的诊断效能,正确理解和分析乳腺癌SELDI-TOF-MS检测结果并论证其用于早期诊断和筛查的准确性。方法:检索2001-01～2007-12的万方中文科技期刊数据库、维普数据库和MEDLINE数据库中关于利用SELDI-TOF-MS技术早期诊断乳腺癌的中、英文文献,对纳入文献进行质量评价、异质性检验,用统计分析软件计算综合受试者工作特征(SROC)曲线方程。结果:共检索到相关文献62篇,对其中8篇符合纳入标准的文献数据进行了Meta分析,样本量735例,综合灵敏度、特异度和综合优势比分别为85.55%、79.18%和22.90,SROC曲线下面积为0.90。结论:SELDI-TOF-MS技术对早期乳腺癌的诊断具有重要价值。
Objective： To assess overall diagnostic value of SELDI-TOF-MS in early breast cancer. Methods： Relevant articles in English and Chinese published from January 2001 to December 2007 were searched for in MEDLINE, Weipu and Wanfang full-text data bases. After elicited articles were evaluated, the pooled sensitivity, specificity and odds rate were calculated by summary receiver operating characteristic（SROC） curve. Results： From 62 related literatures indexed in the three data bases, 8 articles involving 735 samples were selected out to enter this Meta-analysis. The pooled sensitivity, specificity and odds rate were 85.55%, 79.18% and 22.9 respectively. The area under the SROC curve was 0.90. Conclusion： SELDI-TOF-MS is valuable for early diagnosis of breast cancer.
出处
《生物技术通讯》
CAS
2008年第5期708-710,共3页
Letters in Biotechnology
基金
国家高技术研究发展计划(2006AA02090407)
