存活蛋白和NF-κB在外周T细胞性淋巴瘤中的表达和意义

Expression of Survivin and NF-κB in Peripheral T-cell Lymphoma and Its Significance

本研究旨在探讨存活蛋白和NF-κB在外周T细胞性淋巴瘤中的表达及意义。应用免疫组织化学法检测26例外周T细胞性淋巴瘤组织中存活蛋白和NF-κB的表达,30例良性淋巴组织反应增生被选作对照组。结果发现,外周T细胞性淋巴瘤患者中有21例存活蛋白表达阳性,阳性率为80.8%;17例NF-κB表达阳性,阳性率为65.4%。与对照组相比,具有显著性差异(p<0.01)。实验组中,存活蛋白阳性率与NF-κB阳性率呈正相关。结论:存活蛋白和NF-κB在外周T细胞性淋巴瘤组织中广泛表达,对肿瘤细胞的促增殖和抑凋亡发挥着重要的作用。

This study was aimed to explore the expression of survivin and NF-κB in the peripheral T-cell lymphoma and its significance. Immunohistochemistry method was used to detect the expressions of survivin and NF-κB in 26 cases of lymphosarcoma. 30 cases of benign reactive lymphohistocytosis were selected as control tor analysis. The results showed that the expression of survivin in 21 patients with lymphoma was positive, the positive rate reached to 80.8% ; the expression of NF-κB in 17 cases was positive, the positive rate reached to 65.4%. Compared with the control group, the difference was statistically significant （p 〈 0.01 ）. In the experimental group, the expression level of survivin was positively correlated with the positive rate of NF-κB. It is concluded that survivin and NF-κB widely expressed in lymphoma cells and they play an important role in enhancing proliferation and inhibiting apoptosis of tumor cells.