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法呢醇X受体作用的研究进展 被引量：6

Progression in the study on roles of farnesoid X receptor
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摘要 The farnesoid X receptor(FXR)is a member of the nuclear receptor superfamily.It was studied extensively as a receptor for bile acids at first and found to control the metabolism of bile acids.In the past several years,FXR has been found that besides maintaining the homeostasis of bile acids,it also regulates the metabolism of lipid and carbohydrate,protects hepatocytes,promotes hepatic regeneration,inhibits hepatic fibrosis,regulates intestinal bacterial growth,etc.This article reviews the study progression of FXR,especially in the new discovery of FXR functions. The farnesoid X receptor （FXR） is a member of the nuclear receptor superfamily. It was studied extensively as a receptor for bile acids at first and found to control the metabolism of bile acids. In the past several years, FXR has been found that besides maintaining the homeostasis of bile acids, it also regulates the metabolism of lipid and carbohydrate, protects hepatocytes, promotes hepatic regeneration, inhibits hepatic fibrosis, regulates intestinal bacterial growth, etc. This article reviews the study progression of FXR, especially in the new discovery of FXR functions.
作者 李锋 王吉耀
机构地区 复旦大学附属中山医院消化科
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2008年第10期2072-2076,共5页 Chinese Journal of Pathophysiology
关键词 受体 法呢醇X 胆汁酸类 胆固醇 碳水化合物 Receptors, farnesoid X Bile acids Cholesterol Carbohydrates
分类号 R363 [医药卫生—病理学]
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参考文献37

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同被引文献35

  • 1李灏,姜颖,贺福初.胆汁酸功能及其与肠道细菌相互关系[J].中国生物化学与分子生物学报,2007,23(10):817-822. 被引量：13
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  • 6Watanabe M, Houten SM, Wang L, et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-lc. J Clin Invest, 2004, 113 : 1408-1418.
  • 7Gabbl C, Bertolotti M, Anzivino C, et al. Effects of bile duct ligation and cholie add treatment on fatty liver in two rat models of non-alcoholic fatty liver disease. Dig Liver Dis, 2012,44: 1018- 1026.
  • 8Adorini L, Pruzanski M, Shapiro D. Farnesoid X receptor targeting to treat nonalcoholic Steatohepatitis. Drug Diseov Today, 2012, 17:988-997.
  • 9Zhang Y, Edwards PA. FXR signaling in metabolic disease. FEBS Letters, 2008, 582:10- 18.
  • 10Zhang S, Wang J, Liu Q, et al. Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis. J Hepatol, 2009, 51:380- 388.

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中国病理生理杂志
2008年 第10期

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