实验动物骨髓改良组织病理学评价

A Review of Enhanced Histopathology of Bone Marrow In Laboratory Animals

骨髓组织病理学评价能够提供关于造血系统和药物相关毒性的重要信息,对于某种损伤的诊断,可以使用很多术语。为了提高评价的一致性,近年来,世界各国药品管理和专业学术机构都非常重视诊断术语的标准化,强调使用描述性的而不是解释性的术语。美国毒性病理学会(STP)推荐的"淋巴器官改良组织病理学评价"方法,其作为能够运用的一种工具来协助毒性病理学工作者辩识评价具有免疫调控作用的药物,具有较高学术价值。文中对骨髓的标本制备,基本形态学特征,改良组织病理学诊断要点以及评价方法进行了归纳和概括性介绍,为相关领域的科研人员提供参考。

Histological examination of bone marrow provides important information regarding the hematopoietic system an effects related to drug or chemical toxicity. A variety of terms have been used to identify certain lesions. To improve consistency in evaluation, however, there has been a recent interest by regulatory and professional organizations to standardize dignostic terms, emphasizing the use of descriptive, rather than interpretive, terminology. Society of Toxicologic Pathology （STP） recommend ＂Enhanced Histopathology of lymphoid Tissues＂, which is a tool that the pathologist can use to assist in the identification of immunomodulatory drugs and have higher academic value. The article reviewed the specimen making, basal morphology characteristic of bone marrow and introduced the main feature of diagnosis highlight and evaluation methods in bone marrow so as to provide some useful insights for researchers.