通滞苏润江胶囊治疗膝骨性关节炎89例

Curative Effect of Tongzhisurunjiang Capsule on Osteoarthritis of Knee

目的:探讨通滞苏润江胶囊治疗膝骨性关节炎(OA)的疗效。方法:89例OA患者,按Kellgren-Law-rance的X线分级标准,分为三组:Ⅰ级患者为A组(26例),Ⅱ级患者为B组(48例),Ⅲ级及以上患者为C组(15例),每组分别给予口服通滞苏润江胶囊6粒,bid、疗程3个月。观察治疗前后临床症状的改善情况,应用磁共振成影(MRI)检测关节软骨结构改变情况,应用中医氧分压传感针测定治疗前后局部组织氧分压的变化。结果:MRI检查显示,Ⅰ级、Ⅱ级患者软骨磨损出现明显好转与减少(P<0.05),Ⅲ级及以上患者差异无统计学意义(P>0.05)。而治疗后A、B组的局部氧分压较治疗前明显增高,差异有统计学意义(P<0.01),而C组的局部氧分压变化不明显,差异无统计学意义(P>0.05)。结论:通滞苏润江胶囊能通过改善局部微循环,增加局部氧供给,改善局部组织代谢达到早期控制症状、改善关节功能、保护关节软骨磨损和促进软骨的修复。

Objective：To observe the curative effect of Tongzhisurunjiang Capsule （TC） on osteoarthritis （OA） of Knee. Methods： According to Kellgren-Lawrence grades of X-ray diagnosis, 89 outpatients with OA of knee were divided into group A （26 cases of grade Ⅰ ）, group B （48 cases of grade Ⅱ ） and group C （15 cases of grade Ⅲ ）. All patients were trea ted with oral TC 6 capsules per time and twice a day for 3 months. Before and after treatment, the improvement of clinical symptoms was observed. Magnetic resonance imaging （MRI） was used to detect the structural changes of joint cartilage. Partial pressure of oxygen in local tissues was determined using sensing needles. Results： MRI revealed dramatic amelioration and reduction of joint cartilage abrasion in patients of grade Ⅰ and grade Ⅱ （P〈0.05） , while the changes in patients of grade Ⅲ were insignificant （P〉0.05）. Partial pressure of oxygen in group A and group B were significantly increased after the treatment （P〈0.01）, while there was no obvious change in partial pressure of oxygen in group C and the difference was insignificant （P〉0.05）. Conclusion：TC can control clinical symptoms, promote joint function in the early stage of treatment, protect joint cartilage from abrasion and speed the repair of injured joint cartilage by improving local microcir eulation, increasing local oxygen and improving local tissue metabolism.