罗格列酮联合胰岛素治疗2型糖尿病的效果

COMBINATION OF ROSIGLITAZONE AND INSULIN FOR TYPE 2 DIABETES MELLITUS

目的观察罗格列酮联合胰岛素治疗2型糖尿病的效果及对体质量、胰岛素剂量的影响。方法对37例单用胰岛素治疗效果欠佳的2型糖尿病病人加用罗格列酮治疗，加用罗格列酮治疗12周和24周后分别测定空腹和餐后血糖及糖化血红蛋白（HbA1c），并记录胰岛素剂量、体质量、血压及肝肾功能变化。结果胰岛素联合罗格列酮治疗后12周及24周空腹血糖、餐后2h血糖和HbA1c较治疗前明显下降（t=3.54-5.63，P〈0.01）；24周末体质量增加（t=2.66，P〈0.05），每日胰岛素用量从（78±9）U减至（30±7）U（t=4．36，P〈0.01）。结论单用胰岛素治疗控制不良的2型糖尿病加用罗格列酮治疗，可使血糖得到持续改善，并能减少全天胰岛素用量，改善胰岛素抵抗。

Objective To assess the efficacy of rosiglitazone combined with insulin in treating patients with type 2 diabetes and its influence on body weight and insulin dosage. Methods Thirty-seven patients with poor outcome after treated with insulin alone were enrolled and administered with insulin plus rosiglitazone. HbA1c, fasting and postprandial blood glucose, changes in insulin dosage, body weight, blood pressure,liver and kidney function were determined after 12 and 24 weeks of the treatment. Results HbA1c, and blood glucose reduced obviously after treatment （t=3.54-5.63,P〈0.01）, body weight increased in the end of 24 weeks, insulin dosage lowered （t=2.66,4.36,P〈0.05）. Conclusion For those with poorly controlled type 2 diabetes treated with insulin alone can get a lasting improvement of blood sugar, reduction of insulin dose, and release of insulin resistance by giving rosiglitazone plus insulin.