替米沙坦对高血压病人胰岛素抵抗的影响

EFFECT OF TELMISARTAN ON INSULIN RESISTANCE IN PATIENTS WITH HYPERTENSION

目的比较替米沙坦和氯沙坦对高血压病人胰岛素抵抗的影响。方法42例高血压病人经过4周单盲安慰剂导入期后被随机分为2组,实验组给予替米沙坦80 mg,每天1次,对照组给予氯沙坦50 mg,每天1次,疗程8周;比较两组病人治疗前后空腹血糖、空腹胰岛素和胰岛素敏感指数的变化。结果两组病人治疗前后空腹血糖变化无统计学差异,实验组治疗后空腹胰岛素和胰岛素敏感指数与治疗前比较差异有统计学意义(P<0.01);对照组治疗后空腹胰岛素和胰岛素敏感指数与治疗前比较差异无统计学意义(P>0.05);实验组治疗前后空腹胰岛素和胰岛素敏感指数变化值与对照组比较差异有显著性(t=6.59、6.98,P<0.01)。结论治疗剂量替米沙坦具有提高高血压病人的胰岛素敏感指数,改善高血压病人胰岛素抵抗的作用。

Objective To compare the efficacy of telmisartan with losartan in insulin resistance in hypertensive patients.Methods After four weeks of single-blind placebo transduced period,42 hypertensive patients were randomly divided into experi- mental group （telmisartan 80mg, once per day）, and control group （Iosartan 50 mg, once per day）, for eight weeks for both groups. Fasting blood glucose （FBG）, fasting insulin （FINS）, insulin sensitivity index （ISI） were evaluated at the end of therapy. Results The difference of FBG before and after treatment was not significant in both groups. The differences of FINS and ISI before and after treatment were statistically significant （P〈0.01）; there was no statistical significance in changes of FPG in both groups, while the change of FINS and ISI were significantly different in the experimental group than that in the control （t= 6.59, 6.98;P〈0.01）. Conclusion Therapeutic-dose telmisartan offers effect of increasing insulin sensitivity index and improving insulin resistance in the hypertensive.