血神经元特异性烯醇化酶与远期神经系统发育障碍的关系

Correlation of neuron specific enolase and long-term changes in the development of nervous system disorders

目的探讨脑损伤患儿血中神经元特异性烯醇化酶变化与远期神经系统发育障碍的相关性，以期对新生儿脑损伤预后及时预报，为早期干预提供理论依据。方法选择40例围生期脑损伤薪生儿为研究对象，同时选择20例同期出生的健康新生儿为对照组，两组均于生后72h进行检测血浆神经元特异性烯醇化酶，并对两组定期追踪发育情况，以盖塞尔量表评价，经统计学处理分析神经元特异性烯醇化酶与围生期脑损伤患儿远期神经系统发育障碍的相关性。结果脑损伤组血神经元特异性烯醇化酶浓度为（20．5±6．9）ug／L，明显高于健康对照组的（7．8±3．8）us／L（t=4．85，P〈0．01）；脑损伤组15月龄盏塞尔量表评价发育商可疑组生后3d血神经元特异性烯醇化酶浓度为（17．6±5．1）ug／L，明显高于发育商正常组的（12．07±1．86）ug／L（t=3．73，P〈0．01），发育商异常组生后3d血神经元特异性烯醇化酶浓度为（27±7．4）ug／L，明显高于发育商正常组的（12．07±1．86）ug／L（t=3．94，P〈0．01）。结论神经元特异性烯醇化酶变化可作为早期诊断围生儿脑损伤的主要指标以及远期预后指标。

Objective To investigate the perinatal infant brain damage in the blood of neuron specific enolase and long-term changes in the development of nervous system disorders related to the neonatal brain injury prognosis timely predictions for the early intervention and provide a theoretical basis. Methods 40 cases of perinatal brain injury in newborns were selected for the study,20 patients over the same period of normal newborns assigned to the control groups ,both groups in the 72 hours after birth within the collected blood samples submitted preservation of the neuronspiecific enolase enzyme, and regularly follow-up of the two groups, so as to cover Gesell development scale statistical analysis of neuron specific enolase and perinatal brain damage in children with long-term development of nervous system disorder relevant. Results Brain injury group blood neuronspecific enolase concentrations were higher： 15-month-old brain-injury group scale evaluation of sale to group health suspicious after three days of blood neuronspecific enolase concentrations significantly higher to the development of the normal group. Conclusion Neuronspecifie enolase may change as early diagnosis of perinatal brain injury, as well as the main indicators of the long-term prognosis.