慢性阻塞性肺疾病患者血清细胞间黏附分子-1和可溶性E-选择素的检测及意义

Detection and significance of serum ICAM-t and E-selectin in patients with chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病（COPD）患者血清细胞间黏附分子-1（ICAM-1）和可溶性E-选择素（E—selectin）的检测及意义。方法采用酶联免疫吸附双抗体夹心（ELISA）法，检测60例COPD患者、52例急性加重期患者、52例缓解期患者和30例健康对照者血清1CAM-1和E．selectin水平。结果COPD组、急性加重期患者血清ICAM．1和E—selectin水平明显高于对照组（P〈0．01）；缓解期患者血清ICAM—1和E—electin水平明显低于急性加重期（P〈0．01）；缓解期ICAM．1和E—electin水平高于对照组（P〈0．05）。结论ICAM-1、E—selectin参与了COPD的发生、发展。

Objective To study the detection and significance of serum ICAM-1 and E-selectin in patients with chronic obstructive pulmonary disease （COPD）. Methods Double antibody sandwich quantitative enzyme lined immunosorbent assay （ELISA） method was used to measure the serum levels of serum ICAM-1 and E-selectin in 60 patients with COPD, 52 exacerbated patients,52 stable patients and 30 normal control subjects. Results The levels of serum ICAM-1 and E -selectin in COPD group and exacerbated patients were significantly higher than those in normal controls （P 〈 0. 01 ）; these in stable patients were significantly lower than those of exacerbated patients（ P 〈 0. 01 ）, and significantly higher than those exacerbated patients （ P 〈 0. 05 ）. Conclusion ICAM-1 and E-selectin were involved in occurrance and development process of COPD.