血清瘦素与慢性乙型肝炎合并酒精性肝病肝纤维化的关系

The relationship between serum leptin and fibrosis in patients with chronic hepatitis B incorporate alcoholic liver disease

目的研究血清瘦素与慢性乙型肝炎合并酒精性肝病（CHB＋ALD）肝纤维化的关系。方法选择CHB＋ALD患者17例、肝硬化（LC）15例、慢性乙型肝炎（CHB）19例，以12例男性健康受试者（NC）为对照组。采用ELISA法测定各组血清瘦素水平，同步检测血清肝纤维化指标透明质酸（HA）、层粘连蛋白（LN）、前胶原蛋白（PCⅢ）和Ⅳ型胶原（Ⅳ-C），对结果进行分析。结果CHB＋ALD组血清瘦素水平（6．79±24．12）ug/L高于对照组（4．27±7．18）ug／L（P〈0．05），单纯CHB组差异无统计学意义，CHB＋ALD组患者肝纤维化四项指标高于单纯CHB组及NC组；CHB＋ALD组血清瘦素水平与血清肝纤维化四项指标呈正相关（P〈0．05或P〈0．01）。结论血清瘦素是CHB＋ALD患者肝纤维化形成的促进因子之一。

Objective To study the relationship between serum leptin and fibrosis in chronic hepatitis B incorporate alcoholic liver disease（ CHB ＋ ALD） patients. Methods Select 17 male patients with CHB ＋ ALD, 15 male patients with liver cirrhosis（LC） ,19 male patients with chronic hepatitis B（CHB） and 12 male healthy persons as normal control （NC）. Serum leptin is detected by ELISA in 63 patients. Serum levels of fibrosis markers （HA, LN, PC Ⅲ, Ⅳ-C） are determined at the same time. Results Serum leptin level in CHB ＋ ALD are significantly higher than those of the NC （6.79 ±24.12） ug/L vs （4.27 ± 7.18） ug/L（P 〈0.05）. There is no significant difference between patients with CHB and the NC. The four fibrosis markers in CHB ＋ ALD patients are significantly higher than that of men both in the CHB and the NC. There are significant correlations between both serum leptin level and quadfinomial fibrosis markers （ P 〈 0.05 or P 〈 0.01 ）. Conclusion That serum leptin level is one accelerate gene in the fibrosis formation in patients with CHB ＋ ALD.