血清胃蛋白酶原Ⅰ和癌胚抗原联合检测在良恶性胃溃疡鉴别诊断中的应用

Combined Determination of Serum PG and CEA and its Clinical Application in Distinctive Diagnosis of Be- nign and Malignant Gastric Ulcer

目的评价联合检测血清胃蛋白酶原Ⅰ（PGI）和癌胚抗原（CEA）临床价值和可行性。方法回顾性分析402例胃溃疡患者的血清PGI和CEA检测结果。结果402例患者中有73例恶变，73例癌性溃疡患者中PGI和CEA阳性表达分别为38和47例，两者皆表达阳性为22例。联合检测结果阳性63例，单独PGI和CEA检测与联合检测差异有统计学意义（P值分别〈0．05和0．01）。结论对癌性溃疡患者，与单独检测相比，PGI和CEA联合检测提高了灵敏性，是临床上值得推广的一种方法。

Objective The aim of this study was to evaluate the clinical value and the possibilities of measuring the serum levels of pepsinogen Ⅰ （ PG Ⅰ ） and carcinoembryonic antigen （CEA） in 402 patients with gastric ulcer. Methods The patients with gastric ulcer were all confirmed by either operation or gastrofiberscope, and divided into two groups, benign and malignant gastric ulcer. After comparing the relationship between the patients＇clinical appearance and the Radioimmunoassay （RIA） results, （ CEA and PG I ）. Results There were 73 patients were onfirmed malignant gastric ulee in 402 patients. The positive rate of PG was 52. 05% （ 38/73 ）. The positive rate of CEA was 64. 38% （47/73）. Both were 30. 14% （22/73）. Then there were 63（63/73） patients who was positive in the combined determination. Solo determination＇s positive rate of CEA and PG were significantly different from the combined determination. （ P 〈 0. 05 and 0. 01 ） Conclusions Feasibility and the necessity of combined determination were evaluated. Compared with solo determination, for patients with malignant gastric ulcer, it was more sensitive to determine and analysis the serum levels of PG I and CEA synthetically. So it is recommended to popularize the combined determination of serum PG I and CEA in clinical distinctive diagnosis of benign and malignant gastric ulcer.