交叉反应组(CREGs)配型原则在肾移植中的应用研究

Study of CREG zygosity principles applied in kidney transplantation

目的:探讨交叉反应组(CREGs)配型在肾移植中的应用价值。方法:对173例肾移植患者分别采用CREGs配型原则和HLA配型原则的配型情况并对其术后急性排斥反应情况进行相关分析。结果:HLA配型A、B、DR位点0(抗原错配)MM的比率分别为7.51%、4.04%、3.46%,2MM的比率分别为39.88%、65.31%、58.38%;而应用CREGs配型A、B、DR位点0MM的比率分别为49.71%、30.63%、24.27%,2MM的比率分别为5.20%、12.14%、8.67%。HLA配型A、B、DR位点0MM急性排斥反应发生率分别为21.96%、21.38%、7.51%,2MM分别为22.54%、20.23%、66.67%;CREGs配型A、B、DR位点0MM急性排斥反应发生率分别为21.83%、20.21%、6.14%,2MM分别为22.22%、20.00%、69.82%。结论:CREGs配型原则能够有效提高供肾利用率,是一种新的选择肾移植供-受者的配型的方法。

Objective：To study the applied value of CREG Zygosity Principles in kidney transplantation.Methods：Relationship between HLA CREG zygosity and acute rejection incidence was analyzed in 173 kidney transplantation and the concerned principles were discussed.Results：HLA-A,B,DR antigens of 0 mismatch （MM） were 7.51%,4.04%,3.46%;and those of 2 MM were 39.88%,65.31%,58.38% respectively.Compared in CREGs,A,B,and DR,the 0 MMs were 49.71%,30.63% and 24.27%;whereas 2MMs were only 5.20%,12.14% and 8.67%.In HLA-A,B and DR antigens 0 MM,the incidence of acute rejection was 21.96%,21.38% and 7.51% respectively;and in 2MMs,those were 22.54%,20.23%,and 66.67% respectively.Compared by CREGs A,B and DR 0 MM,acute rejection reached 21.83%,20.21% and 6.14%;and in 2MMs the incidence of acute rejection were 22.22%,20.00% and 69.82%.Conclusion：CREGs model is a novel method of choosing kidney transplantation donor-recipients’s matching.