帕罗西汀并喹硫平治疗伴躯体症状抑郁症的效果

EFFECT OF PAROXETINE COMBINED WITH QUETIAPINE IN THE TREATMENT OF DEPRESSION WITH PHYSICAL SYMPTOMS

目的探讨帕罗西汀并喹硫平治疗伴有躯体症状抑郁症效果和安全性。方法将符合CCMD-3诊断标准并伴有躯体症状的门诊及住院病人60例随机分为两组,分别单用帕罗西汀和帕罗西汀并喹硫平治疗6周。采用汉密尔顿抑郁量表（HAMD）于治疗前及治疗后2、4、6周进行疗效评定,采用副反应量表（TESS）评定药物副反应。结果帕罗西汀并喹硫平组疗效优于单用帕罗西汀组（uc=2.42,P〈0.05）,两组治疗后HAMD评分差异有显著性（t=4.01-7.69,P〈0.001）,两组药物副反应比较无明显差异（P〉0.05）。结论帕罗西汀并喹硫平是治疗伴躯体症状的抑郁症的安全、有效的方法。

Objective To study the effect of paroxetine combined with quetiapine in the treatment of depression with physical symptoms. Methods Sixty patients diagnosed as depression with physical symptoms via the criteria of CCMD-3 were randomly divided into two groups： those receiving paroxetine alone for 6 weeks as group I and the rest receiving paroxetine combined with quetiapine for 6 weeks as group Ⅱ. Clinical efficacy and side effects were evaluated with HAMD and TESS. Results The patients group Ⅱ got better outcome than those in group Ⅱ , the improvement rate was 93.3% vs 83.3%, the difference in HAMD score after treatment was significant （P〈0. 001）. But the difference in side effects between the two groups was not significant. Conclusion Paroxetine combined with quetiapine for depression with physical symptoms is an effective and safe therapy.