聚(N-异丙基丙烯酰胺-g-壳聚糖)微粒的制备及其药物缓释性

Preparation of Poly(N-isopropylacrylamide-g-chitosan) Microparticles and Their Controlled Drug Release Property

以三聚磷酸钠为离子交联剂制备壳聚糖颗粒(CS);以N,N′-亚甲基双丙烯酰胺为交联剂,由N-异丙基丙烯酰胺与CS接枝共聚合成了聚(N-异丙基丙烯酰胺-g-壳聚糖)微粒[P(NIPAM-g-CS)],其结构经IR和SEM表征。DSC测试结果显示,P(NIPAM-g-CS)具有温敏性,体积相转变温度33.51℃。P(NIPAM-g-CS)在中性条件下有良好的药物缓释性。

Chitosan microparticles （CS） were prepared using sodium tripolyphosphate as a ionic crosslinking reagent. Poly （ N-isopropylacrylamide-g-chitosan ） particles [ P （ NIPAM-g-CS ） ] were synthesized using N,N＇-methylenebisacrylamide as a crosslinking reagent by graft polymerization between N-isopropylacrylamide（NIPAM） and CS. The structure of P（NIPAM-g-CS） was characterized by IR and SEM. DSC measurement results showed that P（NIPAM-g-CS） exhibited better temperature-sensitivity with the volume phase transition temperature of 33.51 ℃. The controlled drug release behavior of P （NIPAM-g-CS） was investigated at pH 7.4 and different temperatures. The results showed that the P（NIPAM-g-CS） displayed better controlled drug release property.