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α-酮亚胺基酯的不对称乙基锌加成反应

Asymmetric Addition of Diethylzinc to α-Ketoimine Esters
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摘要 首次以手性1,2-二苯基-2-氨基乙醇衍生物为配体实现了乙基锌对α-酮亚胺基酯的不对称加成反应,合成了手性非天然α-氨基酸酯(1,4-加成产物),最高收率67%,最高对映选择性44%。 Derivatives of chiral 1,2-diphenyl-2-aminoalcohol were first used to promoting diethylzine addition to α-ketoimine esters to obtain chiral non-natural α-amino esters（ 1,4-addition products） in the highest yield of 67% with 44%e.e..
作者 雷智权 郑宏杰 闫革新 张晓梅
机构地区 中国科学院成都有机化学研究所 四川大学华西药学院靶向药物教育部重点实验室
出处 《合成化学》 CAS CSCD 2008年第5期567-570,共4页 Chinese Journal of Synthetic Chemistry
基金 国家自然科学基金资助项目(20572109,20772122) 四川省青年科技基金资助项目
关键词 手性氨基醇 二乙基锌 α-酮亚胺基酯 手性α-氨基酸酯 ehiral amino alcohol diethylzinc ot-ketoimine ester ehiral α-amino acid ester
分类号 O625.42 [理学—有机化学]
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参考文献11

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合成化学
2008年 第5期

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