N-乙基-N-甲基氨基甲酰氯的简便合成

A convenient synthesis of N-ethyl-N-methylcarbamoyl chloride

目的研究N-乙基-N-甲基氨基甲酰氯的简便合成方法。方法以苯甲醛和乙胺水溶液为起始原料,形成Schiff碱后经硫酸二甲酯甲基化、水解、中和,得N-甲基乙胺,再与三光气反应得N-乙基-N-甲基氨基甲酰氯。结果目的化合物的化学结构经1HNMR确证,总收率为57.1%。结论改进的合成方法具有原料易得、条件温和、操作简便、收率高等优点。

OBJECTIVE To investigate a practical and convenient process for the synthesis of N - ethyl - N - methylcarbamoyl chloride. METHODS N- methylethylamine was synthesized from benzaldehyde and ethylamine aqueous solution. The key steps included methylation of N - benzylideneethylamine by dimethyl sulfate, followed by hydrolyzation and neutralization with sodium hy- droxide. N - methylethylamine then was reacted with triPhogene to afford the N - ethyl - N - methylcarbamoyl chloride. RESULTS The chemical structure of target compound was determined by 1HNMR. The overall yield was 57. 1%. CONCLUSION This Process, as compared to reported methods, has the advantages of milder reaction condition, simpler process and higher yield.