期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

基于系统生物学的药物研发平台 被引量：2

Systems biology-based platforms for drug research and development
下载PDF
导出
摘要 随着系统生物学的深入发展,出现了许多以此为基础的生物网络模拟软件和药物研发平台。这些软件平台是根据已知药物的作用机制数据,建立生物模拟平台,对新药进行作用机制和临床药效预测,已逐步成为国际制药工业新药研发的新趋势。 Many systems-based bio-simulation network software and platforms for drug research and development have been established with the wide development of systems biology. They are set up on base of the data collected from the actions of the well-known drugs and can predict the actions and clinical efficacy for new drugs, and have gradually become a new tendency in the pharmaceutical industry.
作者 朱小飞 李电东 何琪杨
机构地区 中国医学科学院北京协和医学院医药生物技术研究所
出处 《中国新药杂志》 CAS CSCD 北大核心 2008年第18期1557-1560,共4页 Chinese Journal of New Drugs
基金 国家重点基础研究发展计划(2007CB507406) 国家自然科学基金(30772284)
关键词 系统生物学 新药发现 生物模拟 药物研发平台 systems biology drug discovery bio-simulation platform for drug research ＆ development
分类号 R95 [医药卫生—药学]
  • 相关文献

参考文献23

  • 1US Food and Drug Administration. Challenge and opportunity on the critical path to new medical products[ EB/OL]. [2004 -03 - 16]. http://www, fda. gov/oc/initiatives/critiealpath/whitepaper. html.
  • 2LI WAN PO A. Drug evaluation,drug development and pharmacogenetics:celebrating 30 years of progress [J]. J Clin Pharm Ther, 2005,30(1 ) :1 -4.
  • 3KUMAR N, HENDRIKS BS,JANES KA, et al. Applying computational modeling to drug discovery and development [ J ]. Drug Discov Today,2006,11( 17-18 ) :806 - 811.
  • 4HOOD L. Systems biology:integrating technology, biology and computation [ J ]. Mech Ageing Dev,2003,124 ( 1 ) :9 - 16.
  • 5MICHELSON S. The impact of systems biology and biosimulation on drug discovery and development [ J ]. Mol Biosyst, 2006,2 (6-7) :288 -291.
  • 6谭初兵,杜冠华.系统生物学——药物研发的新动力[J].中国新药杂志,2006,15(19):1626-1630. 被引量：2
  • 7HOOD L, HEATH JR, PHELPS ME, et al. Systems biology and new technologies enable predictive and preventative medicine[J]. Science,2004,306 ( 22 ) : 640 - 643.
  • 8KUNKEL EJ,DEA M,EBENS A,et al. An integrative biology approach for analysis of drug action in models of human vascular inflammation[ J]. FASEB J,2004,18( 11 ) :1279 - 1281.
  • 9KUNKEL EJ,PLAVEC I, NGUYEN D,et al. Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based model[J]. Assay Drug Dev Technol,2004,2 ( 4 ) :431 - 441.
  • 10BERG EL, KUNKEL E J, EVANGELOS H, et al. Characterization of compound mechanisms and secondary activities by BioMAP analysls[ J]. J Phamacol Toxicol Methods ,2006,53 ( 1 ) :67 - 74.

二级参考文献26

  • 1蒋太交,薛艳红,徐涛.系统生物学——生命科学的新领域[J].生物化学与生物物理进展,2004,31(11):957-964. 被引量：23
  • 2AKSENOVA SV, CHURCHA B, DHIMANA A,et al. An integrated approach for inference and mechanistic modeling for advancing drug development [ J ]. FEBS Lett, 2005, 579 ( 8 ) :1878 - 1883.
  • 3NOBEL D. Modeling the heart-from genes to cells to the whole organ [ J ]. Science, 2002, 295 ( 5560 ) : 1678 - 1682.
  • 4SACHS K, PEREZ O, PEERZ D,et al. Causal protein-signaling networks derived from muhiparameter single-cell data [ J ]. Science,2005, 308 (5721) :523 -529.
  • 5FANG Y, OFFENHAEUSSER A. ADMET biosensors: up-to-date issues and strategies[ J]. Med Sci Monit, 2004, 10 ( 12 ) : 127 -132.
  • 6EKINS S, NIKOLSKY Y, NIKOLSKAYA T. Techniques:Application of systems biology to absorption, distribution, metabolism,excretion and toxicity[ J ]. Trends Pharmacol Sci, 2005, 26 (4) :202 - 209.
  • 7COENA M, RUEPPB SU, LINDON JC,et al. Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse [ J ]. J Pharm Biomed Anal, 2004, 35(1) :93 - 105.
  • 8BUGRIM A, NIKOLSKAYA T, NIKOLSKY Y. Early prediction of drug metabolism and toxicity: systems biology approach and modeling[ J]. DDT, 2004, 9( 3 ) : 127 - 135.
  • 9VERPOORTE R, CHOI YH, KIM HK. Ethnopharmacology and systems biology : A perfect holistic match [ J ]. J Ethnopharmacol,2005, 100(1 -2) :53 -56.
  • 10WANG M, LAMERS RJ, KORTHOUT HA,et al. Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology [ J ]. Phytother Res,2005,19(3) :173 - 182.

共引文献16

同被引文献40

引证文献2

二级引证文献13

中国新药杂志
2008年 第18期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部