影响茶碱可德兰口服凝胶药物释放因素的初步考察

Investigation of the factors influencing the release of drug from theophylline Curdlan oral gel

目的:考察影响茶碱可德兰口服凝胶药物释放的因素。方法:以茶碱为模型药物,考察了影响茶碱可德兰口服缓释凝胶释药的处方和工艺因素。结果:可德兰的浓度、制备凝胶的加热温度、加入其他辅料的种类和用量、载药量等因素,对药物的释放影响较为显著。结论:通过调节各影响因素,可以将茶碱可德兰口服凝胶制成缓释制剂。

Objective：To investigate the various factors influencing the release of theophylline from Curdlan oral gel. Methods：Theophylline was used as a model drug and the various factors influencing the release of theo- phylline from Curdlan gel were investigated. Results：The drug release was affected by the concentration of Curdlau,the heating temperature,the sorts and the concentrations of additives etc. Conclusion：Theophylline Curdlan oral sustained-release gel were successfully prepared.