基于秩估计量经验似然分析的加速失效时间模型与预后

ACCELERATED FAILURE TIME MODEL BASED ON EMPIRICAL LIKELIHOOD ANALYSIS OF THE RANK ESTIMATOR AND ITS APPLICATION IN MEDICINE

[目的]介绍加速失效时间模型的一种半参数方法并探讨其在医学中的应用。[方法]用经验似然的方法对模型秩估计量进行分析,以实例说明模型的实际应用。[结果]半参数方法可对回归系数建立可信区间,实例分析结果表明半参数方法与参数法加速失效时间模型结果一致。[结论]半参数加速失效时间模型不需要知道误差项的基准分布,为筛选预后因素提供了一种简便的方法。

[Objective] To introduce the semi-parameter method of accelerated failure time model and its application in medicine. [ Methods ] An empirical likelihood testing procedure was used to analyze the rank estimator of the model, and an example has been illustrated for its application. [ Results] semi-parameter method could establish the confidence interval of regression coefficient, and the results of the example explained the coincidence of the semi-parameter method and the accelerated failure time model of parameter method. [ Conclusion ] The semi-parameter accelerated failure time model does not have to specify the error term distribution and provides a useful method for analyzing prognostic factors.